Document Detail

Fatal acute hepatorenal failure following potassium permanganate ingestion.
MedLine Citation:
PMID:  8839216     Owner:  NLM     Status:  MEDLINE    
Potassium permanganate (KMnO4), a powerful oxidizing agent, is readily available without prescription. Tissue contact produces coagulation necrosis and the lethal consequences of oral ingestion are well described, with most deaths because of airway oedema and obstruction or circulatory collapse. Whilst systemic toxicity is reported, its mechanism is unclear. We describe a case of suicidal ingestion of KMnO4 followed by acute hepatorenal toxicity resulting in the death of the patient. The clinical course bore close resemblance to that of severe paracetamol overdose. We discuss the pathogenesis of the systemic toxicity of KMnO4 and postulate that it is due to oxidative injury from free radicals generated by the absorbed permanganate ion. We recommend that N-acetyl cysteine be given within the first few hours to all patients with potassium permanganate poisoning.
R J Young; J A Critchley; K K Young; R C Freebairn; A P Reynolds; Y I Lolin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human & experimental toxicology     Volume:  15     ISSN:  0960-3271     ISO Abbreviation:  Hum Exp Toxicol     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-12-17     Completed Date:  1996-12-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9004560     Medline TA:  Hum Exp Toxicol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  259-61     Citation Subset:  IM    
Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong.
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MeSH Terms
Accidents, Home
Administration, Oral
Fatal Outcome
Hepatorenal Syndrome / chemically induced
Kidney Failure, Acute / chemically induced*
Liver Failure, Acute / chemically induced*
Potassium Permanganate / administration & dosage,  poisoning*
Reg. No./Substance:
7722-64-7/Potassium Permanganate

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