Document Detail

Fatal pulmonary embolism in a premature neonate after twin-to-twin transfusion syndrome.
MedLine Citation:
PMID:  20603263     Owner:  NLM     Status:  MEDLINE    
Thrombotic events are being increasingly recognized during the neonatal period. An infant girl was born at 29 weeks' gestation after a pregnancy complicated by twin-to-twin transfusion syndrome. After an initial uncomplicated clinical course, her oxygen requirement increased, which was interpreted as an early sign of bronchopulmonary dysplasia. At 3 weeks of age, she suddenly collapsed and died of severe pulmonary hypertension. At autopsy, multiple pulmonary artery emboli and several older renal vein thromboses were found. Results of genetic analyses of the infant and her family were negative for thrombophilia. Although embolism represents a frequent emergency in adults, fatal pulmonary embolism has never, to our knowledge, been described for premature infants. This case suggests that thrombotic events are underdiagnosed and that additional studies are needed to define infants at risk and optimal treatment strategies.
Luregn Jan Schlapbach; Thomas Riedel; Vera Genitsch; Mathias Nelle; Felicity Jane McDougall
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-07-05
Journal Detail:
Title:  Pediatrics     Volume:  126     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-03     Completed Date:  2010-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e483-7     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Bern, Bern, Switzerland.
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MeSH Terms
Blood Transfusion / methods*
Diseases in Twins*
Fetofetal Transfusion*
Infant, Newborn
Infant, Premature
Pulmonary Embolism / radiography,  therapy*
Radiography, Thoracic

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