Document Detail

Fatal massive hemoptysis in a patient on low-dose oral prednisone: chronic necrotizing pulmonary aspergillosis.
MedLine Citation:
PMID:  17319045     Owner:  NLM     Status:  MEDLINE    
We report a case of chronic necrotizing aspergillosis in a 74-year-old man with chronic lung disease, who was on low-dose prednisone. The patient was treated with various antibiotics but had no improvement. Sample obtained via bronchoscopy grew Aspergillus, and the patient was started on lipid formulation amphotericin B. Three days after admission the patient developed fatal massive hemoptysis, presumably secondary to acquired systemic-to-pulmonary vascular communication. This is an unusual presentation of a rare manifestation of pulmonary aspergillosis. A high index of suspicion is needed to diagnose this susceptible patients.
Bobbak Vahid; Paul Marik
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Respiratory care     Volume:  52     ISSN:  0020-1324     ISO Abbreviation:  Respir Care     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-02-23     Completed Date:  2007-03-20     Revised Date:  2008-02-19    
Medline Journal Info:
Nlm Unique ID:  7510357     Medline TA:  Respir Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  56-8     Citation Subset:  IM    
Department of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
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MeSH Terms
Aspergillosis, Allergic Bronchopulmonary* / complications,  drug therapy,  pathology
Aspergillus fumigatus / isolation & purification
Chronic Disease
Fatal Outcome
Glucocorticoids / administration & dosage*,  therapeutic use
Hemoptysis / diagnosis,  etiology*
Lung / microbiology,  pathology,  radiography
Prednisone / administration & dosage*,  therapeutic use
Severity of Illness Index
Tomography, X-Ray Computed
Reg. No./Substance:
0/Glucocorticoids; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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