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Fatal Arrhythmogenic Right Ventricular Cardiomyopathy in 2 Related Subadult Chimpanzees (Pan troglodytes).
MedLine Citation:
PMID:  23988399     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cardiovascular disease is increasingly recognized as an important cause of morbidity and mortality in captive chimpanzees (Pan troglodytes). This report records 2 cases of sudden cardiac death in closely related subadult captive chimpanzees with marked replacement fibrosis and adipocyte infiltration of the myocardium, which resemble specific atypical forms of the familial human disease arrhythmogenic right ventricular cardiomyopathy. Changes were consistent with left-dominant and biventricular subtypes, which are both phenotypic variants found within human families with familial arrhythmogenic right ventricular cardiomyopathy. Previously reported fibrosing cardiomyopathies in chimpanzees were characterized by nonspecific interstitial fibrosis, in contrast to the replacement fibrofatty infiltration with predilection for the outer myocardium seen in these 2 cases. To the authors' knowledge, this case report is the first to describe cardiomyopathy resembling arrhythmogenic right ventricular cardiomyopathy in nonhuman primates and the first to describe left-dominant arrhythmogenic cardiomyopathy-type lesions in an animal.
Authors:
L J Tong; E J Flach; M N Sheppard; A Pocknell; A A Banerjee; A Boswood; T Bouts; A Routh; Y Feltrer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-8-29
Journal Detail:
Title:  Veterinary pathology     Volume:  -     ISSN:  1544-2217     ISO Abbreviation:  Vet. Pathol.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-8-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Veterinary Department, London Zoo, Regents Park, London, UK.
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