Document Detail

Fatal Acute Necrotizing Eosinophilic Myocarditis Temporally Related to Use of Adalimumab in a Patient With Relapsing Polychondritis.
MedLine Citation:
PMID:  24048108     Owner:  NLM     Status:  Publisher    
Tumor necrosis factor α (TNF-α) antagonists are being increasingly used as maintenance therapies for rheumatic diseases, and therefore knowledge of their adverse effects is important. We report a case of fatal acute necrotizing eosinophilic myocarditis temporally related to use of a second course of the TNF-α antagonist, adalimumab. A 51-year-old woman with relapsing polychondritis took adalimumab 2 weeks before presenting with acute myocarditis. Within hours of presentation to the emergency department, she had cardiac arrest due to fulminant heart failure. Autopsy demonstrated necrotizing eosinophilic myocarditis. This is a rare cause of fulminant heart failure. This is the first report of a TNF-α antagonist potentially associated with acute necrotizing eosinophilic myocarditis.
Rosemary Adamson; Yusuf Yazici; Edward S Katz; Stewart G Greisman; David Steiger
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-17
Journal Detail:
Title:  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases     Volume:  -     ISSN:  1536-7355     ISO Abbreviation:  J Clin Rheumatol     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-9-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9518034     Medline TA:  J Clin Rheumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the *Division of Pulmonary & Critical Care Medicine, University of Washington School of Medicine, Seattle, WA; and †Department of Rheumatology and ‡Division of Cardiology, New York University; §Division of Rheumatology, Department of Medicine, St Luke's Roosevelt Hospital Center; and ∥Division of Pulmonary, Critical Care & Sleep Medicine, New York University, New York, NY.
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