Document Detail


Fat synthesis and adiposity regulation in Caenorhabditis elegans.
MedLine Citation:
PMID:  19181539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Understanding the regulation of fat synthesis and the consequences of its misregulation is of profound significance for managing the obesity epidemic and developing obesity therapeutics. Recent work in the roundworm Caenorhabditis elegans has revealed the importance of evolutionarily conserved pathways of fat synthesis and nutrient sensing in adiposity regulation. The powerful combination of mutational and reverse genetic analysis, genomics, lipid analysis, and cell-specific expression studies enables dissection of complicated pathways at the level of a whole organism. This review summarizes recent studies in C. elegans that offer insights into the regulation of adiposity by conserved transcription factors, insulin and growth factor signaling, and unsaturated fatty acid synthesis. Increased understanding of fat-storage pathways might lead to future obesity therapies.
Authors:
Jennifer L Watts
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-01-31
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  20     ISSN:  1043-2760     ISO Abbreviation:  Trends Endocrinol. Metab.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-02     Completed Date:  2009-05-29     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58-65     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Adiposity / physiology*
Animals
Appetite Regulation / physiology
Caenorhabditis elegans / metabolism*,  physiology*
Fatty Acid Desaturases / physiology
Fatty Acids / biosynthesis
Feeding Behavior / physiology
Homeostasis / physiology
Humans
Models, Biological
Signal Transduction / physiology
Grant Support
ID/Acronym/Agency:
DK074114/DK/NIDDK NIH HHS; R01 DK074114/DK/NIDDK NIH HHS; R01 DK074114-04/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; EC 1.14.19.-/Fatty Acid Desaturases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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