Document Detail

Fat oxidation, body composition and insulin sensitivity in diabetic and normoglycaemic obese adults 5 years after weight loss.
MedLine Citation:
PMID:  14513069     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate whether normal glucose-tolerant and type II diabetic overweight adults differ in response to weight regain with regard to substrate oxidation and metabolic parameters.
METHODS: A total of 15 overweight-obese subjects: seven normal glucose tolerant (NGT) and eight with type II diabetes (DM) were restudied 5 y after significant weight loss. Prediet, after 28 days calorie restriction and at 5 y, subjects were characterised for weight, height, waist-to-hip ratio (WHR) and body composition by dual-energy X-ray absorptiometry. Fasting glucose, insulin, leptin and lipid levels were measured and subjects underwent euglycaemic-hyperinsulinaemic clamp (insulin 0.25 U/kg/h for 150 min). Indirect calorimetry was performed resting and in the final 30 min of the clamp. Dietary assessment was by 4-day diet-diary.
RESULTS: Both NGT and DM groups regained weight at 5 y and were not different to prediet. Total body fat (%) and WHR were higher at 5 y compared to prediet in both groups. Fasting glucose was increased in NGT subjects at 5 y, and fasting insulin was higher in both groups at 5 y compared to prediet. Insulin sensitivity (GIR) was similar at 5 y compared to prediet, but at 5 y DM subjects were more insulin resistant than NGT subjects. At 5 y, both DM and NGT groups had significantly reduced basal fat oxidation and no significant suppression of fat oxidation with insulin. Clamp respiratory quotient levels at 5 y were significantly higher in NGT compared to DM subjects.
CONCLUSION: Reduced basal fat oxidation, and reduced variation in substrate oxidation in response to insulin develop with fat regain and fasting hyperinsulinaemia in both NGT and DM obese adults.
A M Poynten; T P Markovic; E L Maclean; S M Furler; J Freund; D J Chisholm; L V Campbell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity     Volume:  27     ISSN:  -     ISO Abbreviation:  Int. J. Obes. Relat. Metab. Disord.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-26     Completed Date:  2003-11-20     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9313169     Medline TA:  Int J Obes Relat Metab Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  1212-8     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / metabolism*
Blood Glucose / analysis
Body Composition / physiology*
Body Constitution / physiology
Carbohydrate Metabolism
Diabetes Mellitus / diet therapy,  metabolism*
Diabetes Mellitus, Type 2 / diet therapy,  metabolism*
Fatty Acids, Nonesterified / blood
Insulin / administration & dosage,  metabolism*
Leptin / blood
Lipids / blood
Middle Aged
Time Factors
Weight Gain / physiology*
Weight Loss / physiology
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Insulin; 0/Leptin; 0/Lipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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