| Fat oxidation at rest predicts peak fat oxidation during exercise and metabolic phenotype in overweight men. | |
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MedLine Citation:
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PMID: 20157319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To elucidate if fat oxidation at rest predicts peak fat oxidation during exercise and/or metabolic phenotype in moderately overweight, sedentary men. DESIGN: Cross-sectional study.Subjects:We measured respiratory exchange ratio (RER) at rest in 44 moderately overweight, normotensive and normoglycemic men and selected 8 subjects with a low RER (L-RER, body mass index (BMI): 27.9+/-0.9 kg m(-2), RER: 0.76+/-0.02) and 8 with a high RER (H-RER; BMI 28.1+/-1.1 kg m(-2), RER: 0.89+/-0.02). After an overnight fast, a venous blood sample was obtained and a graded exercise test was performed. Fat oxidation during exercise was quantified using indirect calorimetry. RESULTS: Peak fat oxidation during exercise was higher in L-RER than in H-RER (0.333+/-0.096 vs 0.169+/-0.028 g min(-1); P<0.01) and occurred at a higher relative intensity (36.2+/-6.6 vs 28.2+/-3.1% VO(2max), P<0.05). Using the International Diabetes Federation criteria, we found that there was a lower accumulation of metabolic risk factors in L-RER than in H-RER (1.6 vs 3.5, P=0.028), and no subjects in L-RER and four of eight subjects in H-RER had the metabolic syndrome. Resting RER was positively correlated with plasma triglycerides (P<0.01) and negatively with plasma free fatty acids (P<0.05), and peak fat oxidation during exercise was positively correlated with plasma free fatty acid concentration at rest (P<0.05). CONCLUSION: A low RER at rest predicts a high peak fat oxidation during exercise and a healthy metabolic phenotype in moderately overweight, sedentary men. |
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Authors:
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M Rosenkilde; P Nordby; L B Nielsen; B M Stallknecht; J W Helge |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-16 |
Journal Detail:
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Title: International journal of obesity (2005) Volume: 34 ISSN: 1476-5497 ISO Abbreviation: Int J Obes (Lond) Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-10 Completed Date: 2010-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101256108 Medline TA: Int J Obes (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 871-7 Citation Subset: IM |
Affiliation:
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Department of Biomedical Sciences, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Basal Metabolism / physiology* Body Mass Index Calorimetry, Indirect Cross-Sectional Studies Exercise / physiology Fasting / physiology Fatty Acids, Nonesterified / blood Humans Lipid Metabolism / genetics, physiology* Male Overweight* / metabolism, physiopathology Oxidation-Reduction Oxygen Consumption / genetics, physiology* Phenotype Rest / physiology Sedentary Lifestyle Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/Triglycerides |
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