Document Detail

Fat metabolism following an intravenous bolus dose of a fat emulsion and carnitine.
MedLine Citation:
PMID:  6426846     Owner:  NLM     Status:  MEDLINE    
Intravenous fat tolerance tests were performed with (carboxyl-14C)-triolein labelled Intralipid in four normal subjects with and without L-carnitine administration, 20 and 25 mg/kg body weight. The pharmacokinetics of L-carnitine was studied simultaneously with measurements of variables reflecting fat metabolism during 4 h. 3-OH-butyrate concentration in plasma was higher in all subjects when carnitine was given. No effect of carnitine was found in elimination of the exogenous triglycerides, the 14CO2 activity in expired air, concentration and specific radioactivity of non- esterified fatty acids or glucose in plasma. The data suggest that carnitine may slightly increase fatty acid oxidation in normal subjects provided that increase of 3-OH-butyrate concentration in plasma is the most sensitive variable reflecting fatty acid oxidation of the variables applied in this study.
G Cederblad
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical physiology (Oxford, England)     Volume:  4     ISSN:  0144-5979     ISO Abbreviation:  Clin Physiol     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-06-22     Completed Date:  1984-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309768     Medline TA:  Clin Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  159-68     Citation Subset:  IM    
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MeSH Terms
Carbon Dioxide / analysis
Carbon Radioisotopes / diagnostic use
Carnitine / blood,  diagnostic use*
Fat Emulsions, Intravenous / diagnostic use*
Fatty Acids, Nonesterified / blood
Hydroxybutyrates / blood
Lipid Metabolism*
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Fat Emulsions, Intravenous; 0/Fatty Acids, Nonesterified; 0/Hydroxybutyrates; 124-38-9/Carbon Dioxide; 541-15-1/Carnitine

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