| Fat metabolism following an intravenous bolus dose of a fat emulsion and carnitine. | |
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MedLine Citation:
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PMID: 6426846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intravenous fat tolerance tests were performed with (carboxyl-14C)-triolein labelled Intralipid in four normal subjects with and without L-carnitine administration, 20 and 25 mg/kg body weight. The pharmacokinetics of L-carnitine was studied simultaneously with measurements of variables reflecting fat metabolism during 4 h. 3-OH-butyrate concentration in plasma was higher in all subjects when carnitine was given. No effect of carnitine was found in elimination of the exogenous triglycerides, the 14CO2 activity in expired air, concentration and specific radioactivity of non- esterified fatty acids or glucose in plasma. The data suggest that carnitine may slightly increase fatty acid oxidation in normal subjects provided that increase of 3-OH-butyrate concentration in plasma is the most sensitive variable reflecting fatty acid oxidation of the variables applied in this study. |
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Authors:
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G Cederblad |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical physiology (Oxford, England) Volume: 4 ISSN: 0144-5979 ISO Abbreviation: Clin Physiol Publication Date: 1984 Apr |
Date Detail:
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Created Date: 1984-06-22 Completed Date: 1984-06-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8309768 Medline TA: Clin Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 159-68 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carbon Dioxide / analysis Carbon Radioisotopes / diagnostic use Carnitine / blood, diagnostic use* Fat Emulsions, Intravenous / diagnostic use* Fatty Acids, Nonesterified / blood Female Humans Hydroxybutyrates / blood Lipid Metabolism* Male |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Fat Emulsions, Intravenous; 0/Fatty Acids, Nonesterified; 0/Hydroxybutyrates; 124-38-9/Carbon Dioxide; 541-15-1/Carnitine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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