Document Detail

Fat metabolism following an intravenous bolus dose of a fat emulsion and carnitine.
MedLine Citation:
PMID:  6426846     Owner:  NLM     Status:  MEDLINE    
Intravenous fat tolerance tests were performed with (carboxyl-14C)-triolein labelled Intralipid in four normal subjects with and without L-carnitine administration, 20 and 25 mg/kg body weight. The pharmacokinetics of L-carnitine was studied simultaneously with measurements of variables reflecting fat metabolism during 4 h. 3-OH-butyrate concentration in plasma was higher in all subjects when carnitine was given. No effect of carnitine was found in elimination of the exogenous triglycerides, the 14CO2 activity in expired air, concentration and specific radioactivity of non- esterified fatty acids or glucose in plasma. The data suggest that carnitine may slightly increase fatty acid oxidation in normal subjects provided that increase of 3-OH-butyrate concentration in plasma is the most sensitive variable reflecting fatty acid oxidation of the variables applied in this study.
G Cederblad
Related Documents :
22062746 - Chemical attributes characterizing sticky post-mortem ageing in beef.
17957816 - Detection of a pathway from linoleate to a novel cyclopentenone: cis-12-oxo-10-phytoeno...
11296696 - Peroxisomal beta-oxidation and steatohepatitis.
15037196 - Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial ...
22494266 - Economic evaluation of anti-epileptic drug therapies with specific focus on teratogenic...
12690536 - Variation in nitrogen source utilisation by nine amanita muscaria genotypes from austra...
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical physiology (Oxford, England)     Volume:  4     ISSN:  0144-5979     ISO Abbreviation:  Clin Physiol     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-06-22     Completed Date:  1984-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309768     Medline TA:  Clin Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  159-68     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Carbon Dioxide / analysis
Carbon Radioisotopes / diagnostic use
Carnitine / blood,  diagnostic use*
Fat Emulsions, Intravenous / diagnostic use*
Fatty Acids, Nonesterified / blood
Hydroxybutyrates / blood
Lipid Metabolism*
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Fat Emulsions, Intravenous; 0/Fatty Acids, Nonesterified; 0/Hydroxybutyrates; 124-38-9/Carbon Dioxide; 541-15-1/Carnitine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nutrition and respiratory disease.
Next Document:  Quantitation of elastin production in cultured vascular smooth muscle cells by a sensitive and speci...