Document Detail


Fat metabolism during low-intensity exercise in endurance-trained and untrained men.
MedLine Citation:
PMID:  7810637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Whole body lipid kinetics were evaluated during basal resting conditions, 4 h of treadmill exercise eliciting an oxygen uptake of 20 ml.kg-1.min-1, and 1 h of recovery in five untrained and five endurance-trained men. Glycerol and free fatty acid (FFA) rate of appearance (Ra) values in plasma were determined by infusing [2H5]glycerol and [1-13C]palmitate, respectively, and lipid oxidation was determined by indirect calorimetry. The lipolytic response to 4 h of exercise, expressed as the average glycerol and FFA Ra values, was similar in both trained (9.85 +/- 1.02 and 24.64 +/- 3.76 mumol.kg-1.min-1, respectively) and untrained subjects (11.29 +/- 0.99 and 24.13 +/- 0.39 mumol.kg-1.min-1, respectively). However, mean triglyceride oxidation was greater during exercise in the trained than in the untrained group (7.51 +/- 0.26 and 5.67 +/- 0.51 mumol.kg-1.min-1, respectively; P < 0.001). During recovery, glycerol and FFA Ra values decreased more rapidly in trained than in untrained subjects. We conclude that highly trained male endurance runners use more fat as a fuel during low-intensity exercise than do untrained healthy men despite similar rates of lipolysis and FFA uptake from plasma. Therefore, the increase in fat oxidation must be related to an increased percentage of FFA uptake oxidized, a greater contribution from intramuscular triglyceride stores, or both. Additionally, lipid kinetics return to baseline more rapidly in trained than in untrained subjects after completing an exercise bout of the same absolute intensity.
Authors:
S Klein; E F Coyle; R R Wolfe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  267     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-01-31     Completed Date:  1995-01-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E934-40     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Texas Medical Branch, Galveston 77555.
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MeSH Terms
Descriptor/Qualifier:
Adult
Exercise*
Fatty Acids / metabolism
Glycerol / metabolism
Humans
Lipid Metabolism*
Male
Oxidation-Reduction
Physical Endurance*
Running
Triglycerides / metabolism
Grant Support
ID/Acronym/Agency:
DK-46017/DK/NIDDK NIH HHS; DK-49989/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Triglycerides; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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