Document Detail

Fat malabsorption in patients before and after total gastrectomy, studied by the triolein breath test.
MedLine Citation:
PMID:  2734589     Owner:  NLM     Status:  MEDLINE    
The feasibility of using the triolein breath test to demonstrate fat malabsorption was evaluated in a prospective study of patients before and after total gastrectomy and Roux-en-Y reconstruction. Two of 11 patients had subnormal fat absorption before the operation, but 1 and 6 months after the operation 9 of 11 patients had subnormal fat absorption. Peak expiratory 14CO2 (median (range] at the three investigations was 3.9%/h (2.1-5.9%/h), 2.1%/h (1.4-4.5%/h), and 2.0%/h (1.2-6.0%/h), respectively. Patients who underwent a Nissen fundoplication were used as controls. They had normal fat absorption both before and after operation. Serum amylase was not appreciably affected by total gastrectomy and was similar to control values. In contrast, serum albumin decreased 1 month after gastrectomy and recovered after 6 months. In control patients pre- and post-operative albumin concentrations did not differ and were comparable to preoperative albumin values in the total gastrectomy group. The lowered fat absorption may be explained by duodenal bypass with decreased pancreatic stimulation, and it may in part explain the weight loss in patients operated on with total gastrectomy.
B Walther; C Clementsson; S Vallgren; I Ihse; B Akesson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  24     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-07-20     Completed Date:  1989-07-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  309-14     Citation Subset:  IM    
Dept. of Surgery, University Hospital, Lund, Sweden.
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MeSH Terms
Anastomosis, Roux-en-Y / adverse effects*
Breath Tests*
Dietary Fats / metabolism*
Follow-Up Studies
Gastrectomy / adverse effects*
Malabsorption Syndromes / etiology*
Middle Aged
Prospective Studies
Stomach Neoplasms / metabolism*,  surgery
Triolein / diagnostic use*
Reg. No./Substance:
0/Dietary Fats; 122-32-7/Triolein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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