Document Detail

Fat intolerance depends on rapid gastric emptying.
MedLine Citation:
PMID:  10063919     Owner:  NLM     Status:  MEDLINE    
Patients with fat intolerance complain of early satiety, bloating, nausea, and vomiting. Since these symptoms are similar to those of patients with postgastrectomy dumping syndrome, we hypothesized that fat intolerance may be associated with early, rapid gastric emptying. Using a three-meal gastric emptying study, we compared gastric emptying in nine patients with a history of fat intolerance and nine normal volunteers. On three separate days, 500-ml radiolabeled test meals containing 0, 15, or 60 g of fat were studied. The percentages of the test meal emptied at 15 and 60 min were analyzed by repeated measures two-way ANOVA. At 15 min (p < 0.05) but not 60 min, gastric emptying was faster in patients than normals. Gastric emptying at 15 min (p < 0.001) and 60 min (p < 0.001) depended on the dose of fat. We conclude that fat intolerance is associated with early, rapid gastric emptying.
H C Lin; G W Van Citters; X T Zhao; A Waxman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  44     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-03-22     Completed Date:  1999-03-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  330-5     Citation Subset:  AIM; IM    
Department of Medicine, CSMC Burns & Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048-1869, USA.
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MeSH Terms
Dietary Fats / adverse effects*,  metabolism
Gastric Emptying / physiology*
Middle Aged
Reg. No./Substance:
0/Dietary Fats

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