Document Detail

Fat in the intestine as a regulator of appetite--role of CCK.
MedLine Citation:
PMID:  15621067     Owner:  NLM     Status:  MEDLINE    
The present review summarizes the appetite-suppressing effects of intestinal fat in the regulation of food intake in humans, with a special focus on the role of cholecystokinin (CCK). Current evidence supports a role for intestinal fat (especially long-chain free fatty acids) acting via the peptide CCK as a physiological satiety pathway. The regulation of satiety is, however, complex and it is not surprising that multiple control systems exist. It is interesting to note that nutrients, such as hydrolysis products of fat in the small intestine, stimulate the release of satiety peptides, such as CCK or PYY, that serve as satiety signals. CCK, released from the gastrointestinal tract by the local action of digested food, exerts various functions: stimulation of gallbladder contraction and exocrine pancreatic secretion, inhibition of gastric emptying, and inhibition of appetite. CCK functions therefore (1) as a positive feedback signal to stimulate digestive processes and (2) as negative feedback signal to limit the amount of food consumed during an individual meal.
Christoph Beglinger; Lukas Degen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Physiology & behavior     Volume:  83     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-28     Completed Date:  2005-03-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  617-21     Citation Subset:  IM    
Division of Gastroenterology, University Hospital, CH-4031 Basel, Switzerland.
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MeSH Terms
Appetite / drug effects*,  physiology
Cholecystokinin / physiology*
Eating / drug effects
Fats / pharmacology*
Intestines / drug effects*,  physiology
Models, Biological
Reg. No./Substance:
0/Fats; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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