Document Detail


Fat-free MRI based on magnetization exchange.
MedLine Citation:
PMID:  20146235     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An MRI technique is proposed for complete fat signal elimination. This approach exploits the fact that water rapidly exchanges magnetization with protons in protein and membrane phospholipid of tissue and cells but does not exchange magnetization with triglyceride or fat protons in the tissue. Saturation of the proton signal from protein and membrane phospholipid thus results in partial saturation of the water proton signal, allowing acquisition of an image including a portion of the water signal and the full fat signal. Subtraction of this image from the standard image, containing both water and fat signals, results in an image in which all fat signal is cancelled. This fat-free image is sensitive to magnetization transfer and to water density and relaxation time, providing the possibility of additional contrast. Unlike most fat suppression techniques, this method is not compromised by the static or radiofrequency field heterogeneity and is equally efficient for all fat resonances independent of their chemical shift frequency.
Authors:
Jin-Hong Chen; H Carl Le; Jason A Koutcher; Samuel Singer
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  63     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-03     Completed Date:  2010-06-09     Revised Date:  2010-09-27    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  713-8     Citation Subset:  IM    
Copyright Information:
(c) 2010 Wiley-Liss, Inc.
Affiliation:
Sarcoma Disease Management Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / pathology*
Algorithms
Humans
Image Enhancement / methods*
Image Interpretation, Computer-Assisted / methods*
Liposarcoma / pathology*
Magnetic Resonance Imaging / methods*
Obesity / pathology*
Reproducibility of Results
Sensitivity and Specificity
Subtraction Technique*
Tumor Cells, Cultured
Grant Support
ID/Acronym/Agency:
P01 CA047179/CA/NCI NIH HHS; P01 CA047179-15A2/CA/NCI NIH HHS; P30 CA08748/CA/NCI NIH HHS; U24CA83084/CA/NCI NIH HHS
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