| Fat embolism in severely injured patients. | |
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MedLine Citation:
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PMID: 1190686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Forty-five patients with severe blunt injuries were examined during eight posttraumatic days. At random, 14 patients were given three doses of methylprednisolone intravenously; 10 mg/kg at 8-hour intervals. Fat embolism syndrome was diagnosed in 13/45 patients, only one of whom had received corticosteroid (p = 0.03). Shock, acidosis and elevated plasma catecholamines showed no correlation with the occurrence of fat embolism syndrome. Platelet counts immediately after trauma were significantly lower in the fat embolism patients than in the other trauma patients, indicative of early platelet aggregation. Prophylactically administered methylprednisolone in pharmacological doses appeared to inhibit the emergence of fat embolism syndrome. |
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Authors:
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P Lepistö; V Avikainen; A Alho; A Jäättelä; E Karaharju; J Kataja; M Lahdensuu; P Rokkanen; T Tervo |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Annales chirurgiae et gynaecologiae Fenniae Volume: 64 ISSN: 0003-3855 ISO Abbreviation: Ann Chir Gynaecol Fenn Publication Date: 1975 |
Date Detail:
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Created Date: 1976-01-23 Completed Date: 1976-01-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7609198 Medline TA: Ann Chir Gynaecol Fenn Country: FINLAND |
Other Details:
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Languages: eng Pagination: 198-202 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Embolism, Fat
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etiology*,
prevention & control Humans Methylprednisolone / administration & dosage, therapeutic use Wounds, Nonpenetrating / complications* |
| Chemical | |
Reg. No./Substance:
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83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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