Document Detail

Fat embolism in severely injured patients.
MedLine Citation:
PMID:  1190686     Owner:  NLM     Status:  MEDLINE    
Forty-five patients with severe blunt injuries were examined during eight posttraumatic days. At random, 14 patients were given three doses of methylprednisolone intravenously; 10 mg/kg at 8-hour intervals. Fat embolism syndrome was diagnosed in 13/45 patients, only one of whom had received corticosteroid (p = 0.03). Shock, acidosis and elevated plasma catecholamines showed no correlation with the occurrence of fat embolism syndrome. Platelet counts immediately after trauma were significantly lower in the fat embolism patients than in the other trauma patients, indicative of early platelet aggregation. Prophylactically administered methylprednisolone in pharmacological doses appeared to inhibit the emergence of fat embolism syndrome.
P Lepistö; V Avikainen; A Alho; A Jäättelä; E Karaharju; J Kataja; M Lahdensuu; P Rokkanen; T Tervo
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Annales chirurgiae et gynaecologiae Fenniae     Volume:  64     ISSN:  0003-3855     ISO Abbreviation:  Ann Chir Gynaecol Fenn     Publication Date:  1975  
Date Detail:
Created Date:  1976-01-23     Completed Date:  1976-01-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7609198     Medline TA:  Ann Chir Gynaecol Fenn     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  198-202     Citation Subset:  IM    
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MeSH Terms
Embolism, Fat / etiology*,  prevention & control
Methylprednisolone / administration & dosage,  therapeutic use
Wounds, Nonpenetrating / complications*
Reg. No./Substance:

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