| Fat distribution and hemostatic measures in obese children. | |
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MedLine Citation:
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PMID: 9625085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the relation of general and visceral adiposity to plasma hemostatic factors [fibrinogen, D-dimer, and plasminogen activator inhibitor 1 (PAI-1)] in obese boys and girls 7-11 y of age (n = 41). Boys had significantly greater fibrinogen and D-dimer concentrations than girls (P < 0.05). whereas blacks had significantly greater fibrinogen and D-dimer concentrations than whites (P < 0.05). Univariate analyses revealed that fibrinogen was positively associated with percentage body fat (%BF) (r = 0.42, P < 0.01), subcutaneous abdominal adipose tissue (SAAT) (r = 0.40, P < 0.01), total fat mass (r = 0.42, P < 0.01), and body mass index (r = 0.41, P < 0.01). PAI-1 was positively associated with visceral adipose tissue (VAT) (r = 0.49, P < 0.01), SAAT (r = 0.32, P < 0.05), fat-free mass (r = 0.50, P < 0.01), and insulin (r = 0.61, P < 0.001). D-Dimer was positively associated with %BF (r = 0.40, P < 0.01), SAAT (r = 0.37, P < 0.05), total fat mass (r = 0.40, P < 0.01), and body mass index (r = 0.43, P < 0.01). Multiple regression analysis revealed that for fibrinogen, sex and higher %BF explained significant independent portions of the variance. For PAI-1, higher amounts of VAT and fat-free mass were significant predictors. For D-dimer, ethnicity was a significant predictor. These results suggest that general adiposity and VAT may play a role in regulating plasma hemostatic factors in obese children. Even early in childhood, adiposity is associated with unfavorable concentrations of hemostatic factors that are in turn implicated in cardiovascular morbidity and mortality later in life. |
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Authors:
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M A Ferguson; B Gutin; S Owens; M Litaker; R P Tracy; J Allison |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 67 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-06-30 Completed Date: 1998-06-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1136-40 Citation Subset: AIM; IM |
Affiliation:
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Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta 30912-3710, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue* African Continental Ancestry Group Anthropometry Cardiovascular Diseases Child European Continental Ancestry Group Exercise Female Hemostatics / blood* Humans Male Obesity / blood* Risk Factors Sex Factors Tissue Distribution |
| Grant Support | |
ID/Acronym/Agency:
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HL 49549/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hemostatics |
| Comments/Corrections | |
Comment In:
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Am J Clin Nutr. 1998 Jun;67(6):1106-7
[PMID:
9625079
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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