Document Detail


Fat digestion in the stomach of premature infants. I. Characteristics of lipase activity.
MedLine Citation:
PMID:  29953     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipolytic activity was studied in gastric aspirates of 13 premature infants of birth weight 1,050 to 1,786 gm. All infants received a diet of infant formula fed by gastric tube. Gastric aspirates were collected after irrigating the stomach with 2 to 5 ml sterile saline before regular feeding. Lipolytic activity, tested with doubly labeled 3H glyceryl-14 C tripalmitin substrate, was 55.6 +/- 11.7 n mol/min/ml (range 4.2 to 140). The lipolytic activity had a pH optimum of 5.4 and produced partial glycerides (mono and diglycerides), glycerol, and free fatty acids. Lipolysis was inhibited by bile salts. Our findings show that in premature infants, as in adults, digestion of dietary fat starts in the stomach. Since bile salt concentrations are low in premature infants, the amphiphilic reaction products formed (monoglyceride and FFA) could play a significant role in the stabilization of lipid emulsions.
Authors:
M Hamosh; K N Sivasubramanian; C Salzman-Mann; P Hamosh
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  93     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1978-12-27     Completed Date:  1978-12-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  674-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Digestion*
Diglycerides / metabolism
Fatty Acids, Nonesterified / metabolism
Female
Glycerides / metabolism
Glycerol / metabolism
Humans
Hydrogen-Ion Concentration
Hydrolysis
Infant, Newborn
Infant, Premature*
Lipase / metabolism*
Lipid Metabolism*
Male
Stomach / enzymology,  metabolism*
Triglycerides / metabolism
Chemical
Reg. No./Substance:
0/Diglycerides; 0/Fatty Acids, Nonesterified; 0/Glycerides; 0/Triglycerides; 56-81-5/Glycerol; EC 3.1.1.3/Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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