Document Detail

Fat consumption and its association with age-related macular degeneration.
MedLine Citation:
PMID:  19433719     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate associations between past dietary fat intake and the prevalence of age-related macular degeneration (AMD). METHODS: Six thousand seven hundred thirty-four participants aged 58 to 69 years in 1990-1994 took part in this cohort study. Participants' nutrient intakes were estimated from a food frequency questionnaire at baseline. At follow-up from 2003 to 2006, digital macula photographs of both eyes were evaluated for early and late AMD signs. Logistic regression was used to estimate odds ratios, with adjustment for age, smoking, and other potential confounders. RESULTS: Higher trans-unsaturated fat intake was associated with an increased prevalence of late AMD; the odds ratio comparing the highest with the lowest quartile of trans fat was 1.76 (95% confidence interval, 0.92-3.37; P = .02). Higher omega-3 fatty acid intake (highest quartile vs lowest quartile) was inversely associated with early AMD (odds ratio, 0.85; 95% confidence interval, 0.71-1.02; P = .03). Olive oil intake (> or =100 mL/week vs <1 mL/week) was associated with decreased prevalence of late AMD (odds ratio, 0.48; 95% confidence interval, 0.22-1.04; P = .03). No significant associations with AMD were observed for intakes of fish, total fat, butter, or margarine. CONCLUSION: A diet low in trans-unsaturated fat and rich in omega-3 fatty acids and olive oil may reduce the risk of AMD.
Elaine W-T Chong; Luibov D Robman; Julie A Simpson; Allison M Hodge; Khin Zaw Aung; Theresa K Dolphin; Dallas R English; Graham G Giles; Robyn H Guymer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  127     ISSN:  1538-3601     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-12     Completed Date:  2009-05-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  674-80     Citation Subset:  AIM; IM    
Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia.
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MeSH Terms
Dietary Fats, Unsaturated / administration & dosage*
Energy Intake
Fatty Acids, Omega-3 / administration & dosage
Macular Degeneration / epidemiology*,  etiology
Middle Aged
Odds Ratio
Prospective Studies
Risk Factors
Trans Fatty Acids / administration & dosage*
Victoria / epidemiology
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fatty Acids, Omega-3; 0/Trans Fatty Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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