Document Detail

Fat chance for longevity.
MedLine Citation:
PMID:  23431052     Owner:  NLM     Status:  MEDLINE    
The health benefits of specific fatty acids and physiological roles of fat metabolism are important subjects that are still poorly understood. In this issue of Genes & Development, O'Rourke and colleagues (pp. 429-440) uncovered a role for lipase-generated ω-6 fatty acids in promoting autophagy and, consequently, life span extension under both fed and fasting conditions. The impact of this finding is discussed with regard to the nutritional value of ω-6 fatty acids and regulatory functions of fat metabolism beyond its well-known role in energy storage.
Marina Kniazeva; Min Han
Publication Detail:
Type:  Comment; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genes & development     Volume:  27     ISSN:  1549-5477     ISO Abbreviation:  Genes Dev.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-22     Completed Date:  2013-04-09     Revised Date:  2013-08-18    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  351-4     Citation Subset:  IM    
Department of Molecular, Cell, and Developmental Biology, Howard Hughes Medical Institute, University of Colorado at Boulder, Boulder, Colorado 80309, USA.
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MeSH Terms
Autophagy / physiology*
Caenorhabditis elegans / physiology*
Fatty Acids, Omega-6 / metabolism*
Longevity / physiology*
Grant Support
//Howard Hughes Medical Institute
Reg. No./Substance:
0/Fatty Acids, Omega-6
Comment On:
Genes Dev. 2013 Feb 15;27(4):429-40   [PMID:  23392608 ]

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