Document Detail

Fat cell metabolism in different regions in women. Effect of menstrual cycle, pregnancy, and lactation.
MedLine Citation:
PMID:  4008649     Owner:  NLM     Status:  MEDLINE    
Adipose tissue lipolysis and lipoprotein lipase (LPL) activity were studied in biopsies from the femoral and abdominal depots in healthy women during early or late menstrual cycle, pregnancy, and the lactation period. When the differences in cell size were taken into account, basal lipolysis was similar in both regions in nonpregnant women. During lactation, however, lipolysis was significantly higher in the femoral region. The lipolytic effect of noradrenaline (10(-6) M) was significantly less in the femoral region in the nonpregnant women and during early pregnancy. However, the lipolytic response was the same in both regions in lactating women. LPL activity was higher in the femoral than in the abdominal region except during lactation when a marked decrease in the LPL activity was seen in the femoral region. The LPL activity in the abdominal region remained unchanged in all patient groups. The results imply that in both nonpregnant and pregnant women lipid assimilation is favored in the femoral depot. During lactation, however, the metabolic pattern changes; the LPL activity decreases and lipid mobilization increases in this depot. These changes are much less pronounced in the abdominal region. Thus, fat cells from different regions show a differential response during pregnancy and lactation. These results suggest that the adipose tissue in different regions may have specialized functions.
M Rebuffé-Scrive; L Enk; N Crona; P Lönnroth; L Abrahamsson; U Smith; P Björntorp
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  75     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-07-30     Completed Date:  1985-07-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1973-6     Citation Subset:  AIM; IM    
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MeSH Terms
Adipose Tissue / cytology,  metabolism*
Glycerol / metabolism
Hormones / blood
Lipid Mobilization
Lipoprotein Lipase / metabolism
Reg. No./Substance:
0/Hormones; 56-81-5/Glycerol; EC Lipase

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