| Fat distribution, aerobic fitness, blood lipids, and insulin sensitivity in African-American and European-American women. | |
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MedLine Citation:
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PMID: 19661963 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to determine independent relationships of intra-abdominal adipose tissue (IAAT), leg fat, and aerobic fitness with blood lipids and insulin sensitivity (S(i)) in European-American (EA) and African-American (AA) premenopausal women. Ninety-three EA and ninety-four AA with BMI between 27 and 30 kg/m(2) had IAAT by computed tomography, total fat and leg fat by dual-energy X-ray absorptiometry, aerobic fitness by a graded exercise test, African admixture (AFADM) by ancestry informative markers, blood lipids by the Ektachem DT system, and S(i) by glucose tolerance test. Independent of age, aerobic fitness, AFADM, and leg fat, IAAT was positively related to low-density lipoprotein-cholesterol (LDL-C), cholesterol-high-density lipoprotein (HDL) ratio, triglycerides (TGs), and fasting insulin (standardized beta varying 0.16-0.34) and negatively related to HDL-cholesterol (HDL-C) and S(i) (standardized beta -0.15 and -0.25, respectively). In contrast, independent of age, aerobic fitness, AFADM, and IAAT, leg fat was negatively related to total cholesterol, LDL-C, cholesterol-HDL ratio, TGs, and fasting insulin (standardized beta varying -0.15 to -0.21) and positively related to HDL-C and S(i) (standardized beta 0.16 and 0.23). Age was not independently related to worsening of any blood lipid but was related to increased S(i) (standardized beta for S(i) 0.25, insulin -0.31). With the exception of total cholesterol and LDL-C, aerobic fitness was independently related to worsened blood lipid profile and increased S(i) (standardized beta varying 0.17 to -0.21). Maintenance of favorable fat distribution and aerobic fitness may be important strategies for healthy aging, at least in premenopausal EA and AA women. |
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Authors:
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Gary R Hunter; Paula C Chandler-Laney; David W Brock; Cristina Lara-Castro; Jose R Fernandez; Barbara A Gower |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-08-06 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 18 ISSN: 1930-7381 ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-02-22 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 274-81 Citation Subset: IM |
Affiliation:
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Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA. ghunter@uab.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adipose Tissue / radiography Adiposity / ethnology* Adult African Americans* Blood Glucose / metabolism Body Mass Index Dyslipidemias / blood, ethnology*, physiopathology, radiography European Continental Ancestry Group* Exercise Test Female Glucose Tolerance Test Humans Insulin / blood Insulin Resistance / ethnology* Intra-Abdominal Fat / radiography Leg Lipids / blood* Middle Aged Obesity / blood, ethnology*, physiopathology, radiography Oxygen Consumption Physical Fitness* Premenopause / ethnology Risk Assessment Risk Factors Tomography, X-Ray Computed United States Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR000032-460702/RR/NCRR NIH HHS; M01 RR000032-475088/RR/NCRR NIH HHS; M01-RR00032/RR/NCRR NIH HHS; P30 DK056336-01/DK/NIDDK NIH HHS; P30-DK56336/DK/NIDDK NIH HHS; R01 DK 49779/DK/NIDDK NIH HHS; R01 DK049779-08/DK/NIDDK NIH HHS; R01 DK049779-09/DK/NIDDK NIH HHS; R01 DK049779-09S1/DK/NIDDK NIH HHS; R01 DK049779-09S2/DK/NIDDK NIH HHS; R01 DK049779-10/DK/NIDDK NIH HHS; R01 DK51684/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Lipids; 11061-68-0/Insulin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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