Document Detail

Fat-1 transgenic mice: a new model for omega-3 research.
MedLine Citation:
PMID:  18042365     Owner:  NLM     Status:  MEDLINE    
An appropriate animal model that can eliminate confounding factors of diet would be very helpful for evaluation of the health effects of nutrients such as n-3 fatty acids. We recently generated a fat-1 transgenic mouse expressing the Caenorhabditis elegans fat-1 gene encoding an n-3 fatty acid desaturase that converts n-6 to n-3 fatty acids (which is absent in mammals). The fat-1 transgenic mice are capable of producing n-3 fatty acids from the n-6 type, leading to abundant n-3 fatty acids with reduced levels of n-6 fatty acids in their organs and tissues, without the need of a dietary n-3 supply. Feeding an identical diet (high in n-6) to the transgenic and wild-type littermates can produce different fatty acid profiles in these animals. Thus, this model allows well-controlled studies to be performed, without the interference of the potential confounding factors of diet. The transgenic mice are now being used widely and are emerging as a new tool for studying the benefits of n-3 fatty acids and the molecular mechanisms of their action.
Jing X Kang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-11-26
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  77     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:    2007 Nov-Dec
Date Detail:
Created Date:  2007-12-10     Completed Date:  2008-04-23     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  263-7     Citation Subset:  IM    
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MeSH Terms
Biomedical Research / methods
Caenorhabditis elegans Proteins / genetics,  metabolism*
Fatty Acid Desaturases / genetics,  metabolism*
Fatty Acids, Omega-3 / metabolism*
Fatty Acids, Omega-6 / metabolism
Mice, Transgenic
Models, Animal*
Grant Support
R01 CA113605/CA/NCI NIH HHS; R01 CA113605-02/CA/NCI NIH HHS; R01CA-11365/CA/NCI NIH HHS
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/fat-1 protein, C elegans; EC 1.14.19.-/Fatty Acid Desaturases

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