| Fasudil Ameliorates disease Progression in Experimental Autoimmune Encephalomyelitis, Acting Possibly Through Antiinflammatory Effect. | |
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MedLine Citation:
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PMID: 22994384 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: The purpose of this investigation was to further explore the mechanism(s) underlying the amelioration in EAE caused by Fasudil, particularly focusing on anti-inflammatory effect. METHODS: We induced a chronic-progressive experimental autoimmune encephalomyelitis (EAE) in B6 mice immunized with myelin oligodendrocyte glycoprotein(35-55) and performed Fasudil intervention in early and late stages of the disease. RESULTS: The administration of Fasudil (40 mg/kg, i.p) had a therapeutic effect in delaying the onset and ameliorating the severity of EAE, accompanied by the improvement in myelination and the decrease in inflammatory cells in spinal cords. Fasudil inhibited TLR-4, p-NF-kB/p65, and inflammatory cytokines (IL-1β, IL-6, and TNF-α) and enhanced IL-10 production in spinal cords. The ratio of arginase/iNOS was enhanced mainly in the spinal cords of EAE mice treated with Fasudil, reflecting a shift toward the M2 (antiinflammation) macrophage/microglia phenotype. The administration of Fasudil also induced the upregulation of CB2 receptor in spinal cords, but did not significantly trigger CB1 receptor. Levels of neurotrophic factors NGF, BDNF, and GDNF in the CNS were not altered by Fasudil. CONCLUSION: Fasudil ameliorates disease progression in EAE, acting possibly through antiinflammatory pathway. |
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Authors:
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Shao-Wei Hou; Chun-Yun Liu; Yan-Hua Li; Jie-Zhong Yu; Ling Feng; Yue-Ting Liu; Ming-Fang Guo; Yong Xie; Jian Meng; Hai-Fei Zhang; Bao-Guo Xiao; Cun-Gen Ma |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-21 |
Journal Detail:
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Title: CNS neuroscience & therapeutics Volume: - ISSN: 1755-5949 ISO Abbreviation: CNS Neurosci Ther Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101473265 Medline TA: CNS Neurosci Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Blackwell Publishing Ltd. |
Affiliation:
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Department of Neurology, Medical School, Institute of Brain Science, Shanxi Datong University, Datong, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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