Document Detail

Fasting urinary calcium/creatinine and hydroxyproline/creatinine values in young women with amenorrhoea and in matched eumenorrhoeic controls.
MedLine Citation:
PMID:  2608225     Owner:  NLM     Status:  MEDLINE    
The present study was undertaken to compare fasting urinary calcium/creatinine (Ca/Cr) and hydroxyproline/creatinine (HP/Cr) values in young amenorrhoeic women with those of age and weight-matched menstruating women and to see whether restoration of menstruation would influence values. Thirty amenorrhoeic patients were matched with 30 controls. Higher Ca/Cr (0.393 (SD 0.213) vs 0.142 (0.89), p less than 0.001) and HP/Cr (0.025 (0.005) vs 0.020 (0.007), p less than 0.005) values were found in patients with hyperprolactinaemia or hypothalamic dysfunction associated with weight loss, anorexia nervosa or excessive exercise (n = 20), suggesting excessive bone loss in these amenorrhoeic patients, who are frequently oestrogen deficient. Furthermore when 9 amenorrhoeic patients with hypothalamic dysfunction became eumenorrhoeic their urinary Ca/Cr values fell (p less than 0.02). However, amenorrhoeic patients with polycystic ovaries (n = 10) had similar Ca/Cr and HP/Cr values as their controls. It is therefore probable that amenorrhoeic patients with polycystic ovaries are not at risk of osteopenia. The present findings suggest measurements of fasting urinary Ca/Cr and HP/Cr values are likely to prove useful in identifying patients with amenorrhoea who are rapidly losing bone, and in assessing their responses to therapy.
A Goulding; B G Rae; R Bland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The New Zealand medical journal     Volume:  102     ISSN:  0028-8446     ISO Abbreviation:  N. Z. Med. J.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-02-14     Completed Date:  1990-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401067     Medline TA:  N Z Med J     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  629-30     Citation Subset:  IM    
Department of Medicine, University of Otago Medical School, Dunedin.
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MeSH Terms
Amenorrhea / etiology,  urine*
Calcium / urine*
Creatinine / urine*
Fasting / urine*
Hydroxyproline / urine*
Hyperprolactinemia / complications
Hypothalamic Diseases / complications
Pituitary Diseases / complications
Polycystic Ovary Syndrome / complications
Reg. No./Substance:
51-35-4/Hydroxyproline; 60-27-5/Creatinine; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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