Document Detail


Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction.
MedLine Citation:
PMID:  9355888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Recent data suggest that triglyceride-rich lipoproteins may play a role in atherogenesis. However, whether triglycerides, as a marker for these lipoproteins, represent an independent risk factor for coronary heart disease remains unclear, despite extensive research. Several methodological issues have limited the interpretability of the existing data. METHODS AND RESULTS: We examined the interrelationships of fasting triglycerides, other lipid parameters, and nonlipid risk factors with risk of myocardial infarction among 340 cases and an equal number of age-, sex-, and community-matched control subjects. Cases were men or women of <76 years of age with no prior history of coronary disease who were discharged from one of six Boston area hospitals with the diagnosis of a confirmed myocardial infarction. In crude analyses, we observed a significant association of elevated fasting triglycerides with risk of myocardial infarction (relative risk [RR] in the highest compared with the lowest quartile=6.8; 95% confidence interval [CI]=3.8 to 12.1; P for trend <.001). Results were not materially altered after control for nonlipid coronary risk factors. As expected, the relationship was attenuated after adjustment for HDL but remained statistically significant (RR in the highest quartile=2.7; 95% confidence interval [CI]=1.4 to 5.5; P for trend=.016). Furthermore, the ratio of triglycerides to HDL was a strong predictor of myocardial infarction (RR in the highest compared with the lowest quartile=16.0; 95% CI=7.7 to 33.1; P for trend <.001). CONCLUSIONS: Our data indicate that fasting triglycerides, as a marker for triglyceride-rich lipoproteins, may provide valuable information about the atherogenic potential of the lipoprotein profile, particularly when considered in context of HDL levels.
Authors:
J M Gaziano; C H Hennekens; C J O'Donnell; J L Breslow; J E Buring
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  96     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-12-09     Completed Date:  1997-12-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2520-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 02215-1204, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cholesterol / blood
Cholesterol Esters / blood
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Fasting
Female
Humans
Lipoproteins, HDL / blood*
Lipoproteins, LDL / blood
Male
Middle Aged
Myocardial Infarction / etiology*
Risk Factors
Triglycerides / blood*
Grant Support
ID/Acronym/Agency:
HL-07575/HL/NHLBI NIH HHS; HL-21006/HL/NHLBI NIH HHS; HL-24423/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cholesterol Esters; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Triglycerides; 57-88-5/Cholesterol

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