Document Detail

Fasting serum ghrelin level is associated with metabolic syndrome in peritoneal dialysis patients.
MedLine Citation:
PMID:  18552255     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Serum ghrelin levels are elevated in uremic patients. However, no data are available on the relationship between metabolic syndrome and serum ghrelin levels in peritoneal dialysis (PD) patients. METHODS: Metabolic syndrome and its components were defined using diagnostic criteria recommended by the International Diabetes Federation. Fasting serum samples were taken from 30 PD patients. Serum ghrelin levels were measured by using a commercial enzyme-linked immunosorbent assay kit. RESULTS: Of the 30 PD patients, 53.3% (16/30) had metabolic syndrome. Fasting serum ghrelin corrected inversely with metabolic syndrome among these PDs patients (p = 0.002). By odds ratio (OR) analysis of metabolic syndrome and metabolic syndrome diagnostic criteria, the predictors for metabolic syndrome are fasting glucose [OR: 39.00; 95% confidence interval (CI): 3.80 to 399.85; p < 0.001], triglycerides (OR: 37.50; 95% CI: 3.64 to 386.51; p < 0.001), and waist circumference (OR: 4.20; 95% CI: 1.95 to 9.03; p < 0.001). Univariate linear regression analysis showed that body weight (r = -0.461, p = 0.010), waist circumference (r = -0.390, p = 0.033), and body mass index (r = -0.438, p = 0.016) were negatively correlated with serum ghrelin, and serum high density lipoprotein [HDL (r = 0.626, p < 0.001)] was positively correlated with serum ghrelin. Multivariate forward stepwise linear regression analysis of the significant variables showed that HDL (R(2) change = 0.392; p < 0.001) was the independent predictor of serum ghrelin in PD patients and explained 39.2% of the variance. CONCLUSIONS: These results indicate an inverse association between circulating fasting ghrelin and metabolic syndrome in PD patients. Serum HDL was associated with serum ghrelin among PD patients.
Chung-Jen Lee; Yi-Maun Subeq; Chih-Hsien Wang; Ru-Ping Lee; Te-Chao Fang; Bang-Gee Hsu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  28 Suppl 3     ISSN:  0896-8608     ISO Abbreviation:  Perit Dial Int     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-16     Completed Date:  2008-11-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  S196-200     Citation Subset:  IM    
Department of Nursing, Tzu Chi University, Hualien, Taiwan.
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MeSH Terms
Blood Glucose
Body Mass Index
Body Weight
Cholesterol, HDL / blood
Ghrelin / blood*
Kidney Failure, Chronic / blood*,  complications,  therapy*
Metabolic Syndrome X / blood*,  complications,  diagnosis*
Middle Aged
Peritoneal Dialysis*
Predictive Value of Tests
Triglycerides / blood
Waist-Hip Ratio
Reg. No./Substance:
0/Blood Glucose; 0/Cholesterol, HDL; 0/Ghrelin; 0/Triglycerides

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