Document Detail

Fasting and postprandial total ghrelin remain unchanged after short-term energy restriction.
MedLine Citation:
PMID:  15070937     Owner:  NLM     Status:  MEDLINE    
Adaptations that promote positive energy balance appear in response to dietary restriction. The aim of this study was to determine whether fasting and postprandial total ghrelin increase in response to short-term energy restriction. Fifteen adult male subjects were subjected to a 4-d energy restricted diet (-800 kcal/d). Body weight and composition, resting energy expenditure, respiratory quotient, fasting and postprandial appetite scores, and fasting and postprandial serum leptin and total ghrelin were determined before and after dietary intervention. Despite the fact that fat mass remained unchanged after the 4 d, fasting (-36%; P </= 0.01) and postprandial serum leptin (-27%; P = 0.01) were significantly reduced. A significant reduction in total ghrelin was observed after the meal (P </= 0.05); however, fasting and postprandial total ghrelin remained unchanged at the end of the intervention. Although leptin was a significant correlate of appetite before and after the intervention, no such associations were noted for total ghrelin. Finally, a significant relation between total ghrelin and respiratory quotient was noted at the onset of the diet (r = 0.63; P </= 0.01). Fasting and postprandial total ghrelin levels remain unchanged after short-term energy restriction despite a significant fall in leptin.
Eric Doucet; Marjorie Pomerleau; Mary-Ellen Harper
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  89     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-08     Completed Date:  2004-05-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1727-32     Citation Subset:  AIM; IM    
School of Human Kinetics, and Department of Biochemistry, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5.
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MeSH Terms
Caloric Restriction*
Energy Intake
Energy Metabolism
Fasting / blood*
Leptin / blood
Peptide Hormones / blood*
Postprandial Period / physiology*
Reference Values
Time Factors
Reg. No./Substance:
0/Ghrelin; 0/Leptin; 0/Peptide Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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