| Fasting and post-prandial adipose tissue lipoprotein lipase and hormone-sensitive lipase in obesity and Type 2 diabetes. | |
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MedLine Citation:
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PMID: 20926921 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Fasting and post-prandial abnormalities of adipose tissue (AT) lipoprotein lipase (LPL) and hormone- sensitive lipase (HSL) activities may have pathophysiological relevance in insulin-resistant conditions. AIM: The aim of this study was to evaluate activity and gene expression of AT LPL and HSL at fasting and 6 h after meal in two insulin-resistant groups - obese with Type 2 diabetes and obese without diabetes - and in non-diabetic normal-weight controls. MATERIAL/SUBJECTS AND METHODS: Nine obese subjects with diabetes, 10 with obesity alone, and 9 controls underwent measurements of plasma levels of glucose, insulin, and triglycerides before and after a standard fat-rich meal. Fasting and post-prandial (6 h) LPL and HSL activities and gene expressions were determined in abdominal subcutaneous AT needle biopsies. RESULTS: The diabetic obese subjects had significantly lower fasting and post-prandial AT heparin-releasable LPL activity than only obese and control subjects (p<0.05) as well as lower mRNA LPL levels. HSL activity was significantly reduced in the 2 groups of obese subjects compared to controls in both fasting condition and 6 h after the meal (p<0.05), while HSL mRNA levels were not different. There were no significant changes between fasting and 6 h after meal measurements in either LPL or HSL activities and gene expressions. CONCLUSIONS: Lipolytic activities in AT are differently altered in obesity and Type 2 diabetes being HSL alteration associated with both insulin-resistant conditions and LPL with diabetes per se. These abnormalities are similarly observed in the fasting condition and after a fat-rich meal. |
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Authors:
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G Costabile; G Annuzzi; L Di Marino; C De Natale; R Giacco; L Bozzetto; P Cipriano; C Santangelo; R Masella; A A Rivellese |
Publication Detail:
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Type: Journal Article Date: 2010-10-04 |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: 34 ISSN: 1720-8386 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-06-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: Italy |
Other Details:
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Languages: eng Pagination: e110-4 Citation Subset: IM |
Affiliation:
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Department of Clinical and Experimental Medicine, Federico II University, Via Pansini 5, 80131 Naples, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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