| Fasting and postabsorptive hepatic glucose and insulin metabolism in hyperthyroidism. | |
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MedLine Citation:
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PMID: 2643338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of thyroid hormone excess on hepatic glucose balances and fractional hepatic extraction of insulin and glucagon was examined in six conscious dogs with catheters in the portal vein, hepatic vein, and femoral artery and Doppler flow probes on the portal vein and hepatic artery. An oral glucose tolerance test was performed before and after the animals were made hyperthyroid by intramuscular thyroxine administration (100 micrograms.kg-1.day-1) for 10 days. In the basal state and after oral glucose, insulin and glucagon levels in the three vessels and the basal fractional hepatic extraction of insulin and glucagon were not significantly modified by thyroid hormone. These results suggest that in short-term thyrotoxicosis insulin secretion is not impaired, and the rise in fasting plasma glucose and increased hepatic glucose production could reflect hepatic insulin resistance, increased availability of precursors for gluconeogenesis, or increased glycogenolysis. Hyperthyroidism significantly increased basal flows in the portal vein (14.7 +/- 0.6 vs. 12.9 +/- 0.5 ml.kg-1.min-1), the hepatic artery (4.8 +/- 0.3 vs. 3.9 +/- 0.2 ml.kg-1.min-1) and vein (19.6 +/- 0.7 vs. 16.9 +/- 0.4 ml.kg-1.min-1), the fasting plasma glucose concentration (104 +/- 3 vs. 92 +/- 2 mg/dl), and basal hepatic glucose output (2.1 +/- 0.2 vs. 1.5 +/- 0.2 mg.kg-1.min-1). It did not alter the nonhepatic splanchnic uptake of glucose, the percent of orally administered glucose that appeared in the portal vein (47 +/- 2 vs. 45 +/- 11%), the percent of hepatic uptake of glucose (59 +/- 11 vs. 74 +/- 22%), or the shape of the glucose tolerance test. |
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Authors:
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N Raboudi; R Arem; R H Jones; Z Chap; J Pena; J Chou; J B Field |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 256 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1989 Jan |
Date Detail:
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Created Date: 1989-02-21 Completed Date: 1989-02-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E159-66 Citation Subset: IM |
Affiliation:
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Department of Medicine, Baylor College of Medicine, Houston, Texas. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity Blood Glucose / metabolism Dogs Fasting* Female Food* Glucagon / blood Glucose / metabolism* Glucose Tolerance Test Hepatic Artery / physiopathology Hepatic Veins / physiopathology Hyperthyroidism / chemically induced, metabolism* Insulin / blood, metabolism* Kinetics Liver / metabolism* Male Portal Vein / physiopathology Splanchnic Circulation Thyroxine |
| Grant Support | |
ID/Acronym/Agency:
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DK-25253/DK/NIDDK NIH HHS; DK-27685/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin; 50-99-7/Glucose; 7488-70-2/Thyroxine; 9007-92-5/Glucagon |
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