Document Detail

Fasting levels of ghrelin covary with the brain response to food pictures.
MedLine Citation:
PMID:  22974271     Owner:  NLM     Status:  MEDLINE    
Ghrelin figures prominently in the regulation of appetite in normal-weighed individuals. The apparent failure of this mechanism in eating disorders and the connection to addictive behavior in general demand a deeper understanding of the endogenous central-nervous processes related to ghrelin. Thus, we investigated processing of pictures showing palatable food after overnight fasting and following a standardized caloric intake (i.e. a 75-g oral glucose tolerance test) using functional magnetic resonance imaging and correlated it with blood plasma levels of ghrelin. Twenty-six healthy female and male volunteers viewed food and control pictures in a block design and rated their appetite after each block. Fasting levels of ghrelin correlated positively with food-cue reactivity in a bilateral network of visual processing-, reward- and taste-related regions, including limbic and paralimbic regions. Notably, among those regions were the hypothalamus and the midbrain where ghrelin receptors are densely concentrated. In addition, high fasting ghrelin levels were associated with stronger increases of subjective appetite during the food-cue-reactivity task. In conclusion, brain activation and subjective appetite ratings suggest that ghrelin elevates the hedonic effects of food pictures. Thereby, fasting ghrelin levels may generally enhance subjective craving when confronted with reward cues.
Nils B Kroemer; Lena Krebs; Andrea Kobiella; Oliver Grimm; Maximilian Pilhatsch; Martin Bidlingmaier; Ulrich S Zimmermann; Michael N Smolka
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-13
Journal Detail:
Title:  Addiction biology     Volume:  18     ISSN:  1369-1600     ISO Abbreviation:  Addict Biol     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-20     Completed Date:  2014-03-10     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  9604935     Medline TA:  Addict Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  855-62     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors, Addiction Biology © 2012 Society for the Study of Addiction.
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MeSH Terms
Appetite / physiology*
Brain / physiology*
Fasting / blood
Functional Neuroimaging / methods
Ghrelin / blood*,  physiology
Glucose Tolerance Test
Hunger / physiology*
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Photic Stimulation / methods
Statistics as Topic
Time Factors
Young Adult
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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