| Fasting Serum Apolipoprotein B-48 Can be a Marker of Postprandial Hyperlipidemia. | |
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MedLine Citation:
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PMID: 21946533 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: Postprandial hyperlipidemia (PH) is thought to be caused by the impaired postprandial metabolism of triglycerides (TG)-rich lipoproteins in both endogenous and exogenous pathways; however, there is no consensus. It is difficult to estimate the presence of PH without performing a time-consuming oral fat loading (OFL) test, so postprandial lipoprotein metabolism was analyzed by measuring the postprandial levels of apolipoprotein (apo) B-48 and apo B-100, and the correlation between postprandial TG increase and fasting apoB-48 levels was assessed to establish a good marker of PH without performing an OFL test.Methods: Ten male normolipidemic subjects were loaded with a high-fat (HF, 1045 kcal) or standard (ST, 566 kcal) meal, and the lipids, apolipoproteins and lipoprotein profiles were analyzed after each meal.Results: TG, apo B-48, remnant-like particles (RLP)-cholesterol and RLP-TG levels were increased and their levels were significantly higher after intake of the HF meal than the ST meal; however, there was no postprandial increase in apo B-100 and LDL-C levels. Postprandial increases in TG levels of CM, VLDL, LDL and HDL were significantly higher after intake of the HF meal than the ST meal. Fasting apo B-48 levels were strongly correlated with the incremental area under the curve of TG after intake of the HF meal, but not the ST meal.Conclusion: Postprandial TG increase was mainly due to increased CM and CM-R, but not VLDL. Measurement of fasting serum apo B-48 may be a simple and useful method for assessment of the existence of PH. |
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Authors:
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Daisaku Masuda; Naohiko Sakai; Taizo Sugimoto; Rika Kitazume-Taneike; Taiji Yamashita; Ryota Kawase; Hajime Nakaoka; Miwako Inagaki; Kazuhiro Nakatani; Miyako Yuasa-Kawase; Kazumi Tsubakio-Yamamoto; Tohru Ohama; Yumiko Nakagawa-Toyama; Makoto Nishida; Masato Ishigami; Yoshiro Masuda; Akifumi Matsuyama; Issei Komuro; Shizuya Yamashita |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-24 |
Journal Detail:
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Title: Journal of atherosclerosis and thrombosis Volume: - ISSN: 1880-3873 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506298 Medline TA: J Atheroscler Thromb Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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