Document Detail


Fasting and post-methionine homocysteine levels in Alzheimers disease and vascular dementia.
MedLine Citation:
PMID:  20209467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study is to compare the basal homocysteine levels in patients with impairment of cognitive status, and in controls, to evaluate if the methionine loading test is able to identify any differences between patients with Alzheimers disease and patients with vascular dementia. We enrolled 56 subjects, 20 with Alzheimers disease, 18 with vascular dementia, and 18 normal controls. The data shown that plasma homocysteine levels both basal and post-methionine load were significantly higher in the two groups of demented patients than in the control group. No significant differences were found between Alzheimers patients and vascular dementia patients. The homocysteine percent increase after a methionine loading test was significantly higher in the controls with respect to the two groups of demented patients. Only in Alzheimers patients were vitamin B(12) basal levels negatively correlated with basal homocysteine levels (p<0.05), while positively correlated with the homocysteine percent increase after load (p<0.05). The study confirms the possible role of chronically elevated homocysteinemia in neuronal degeneration in demented patients. Even if the methionine loading test revealed an abnormal homocysteine metabolism in demented patients, it didnt show any difference among patients with Alzheimers disease and vascular dementia.
Authors:
Paola Villa; Paolo Bosco; Raffaele Ferri; Concetta Perri; Rosanna Suriano; Barbara Costantini; Francesca Macr?; Caterina Proto; Rosa Maria Cento; Antonio Lanzone
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift f?r Vitamin- und Ern?hrungsforschung. Journal international de vitaminologie et de nutrition     Volume:  79     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  2009 May 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  166-72     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Catholic University of Sacred Heart, Rome, Italy. paolo.villa@rm.unicatt.it
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / blood*
Case-Control Studies
Cohort Studies
Dementia, Vascular / blood*
Fasting / blood
Female
Folic Acid / blood
Homocysteine / blood*
Humans
Male
Methionine / administration & dosage*
Statistics, Nonparametric
Vitamin B 12 / blood
Chemical
Reg. No./Substance:
454-28-4/Homocysteine; 59-30-3/Folic Acid; 63-68-3/Methionine; 68-19-9/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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