| Faster lactate transport across red blood cell membrane in sickle cell trait carriers. | |
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MedLine Citation:
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PMID: 16239612 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The physical and physiological behavior of sickle cell trait carriers (AS) is somewhat equivocal under strenuous conditions, although this genetic abnormality is generally considered to be a benign disorder. The occurrence of incidents and severe injuries in AS during exercise might be explained, in part, by the lactic acidosis due to a greater lactate influx into AS red blood cells (RBCs). In the present study, the RBC lactate transport activity via the different pathways was compared between AS and individuals with normal hemoglobin (AA). Sixteen Caribbean students, nine AS and seven AA, performed a progressive and maximal exercise test to determine maximal oxygen consumption. Blood samples were obtained at rest to assess haematological parameters and RBC lactate transport activity. Lactate influxes [total lactate influx and monocarboxylate transporter (MCT-1)-mediated lactate influx] into erythrocytes were measured at four external [14C]-labeled lactate concentrations (1.6, 8.1, 41, and 81.1 mM). The two groups had similar maximal oxygen consumption. Total lactate influx and lactate influx via the MCT-1 pathway were significantly higher in AS compared with AA at 1.6, 41, and 81.1 mM. The maximal lactate transport capacity for MCT-1 was higher in AS than in AA. Although AS and AA had the same maximal aerobic physical fitness, the RBCs from the sickle cell trait carriers took up more lactate at low and high concentrations than the RBCs from AA individuals. The higher MCT-1 maximal lactate transport capacity found in AS suggests greater content or greater activity of MCT-1 in AS RBC membranes. |
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Authors:
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Fagnété Sara; Sara Fagnété; Philippe Connes; Connes Philippe; Olivier Hue; Hue Olivier; Mona Montout-Hedreville; Montout-Hedreville Mona; Maryse Etienne-Julan; Etienne-Julan Maryse; Marie-Dominique Hardy-Dessources; Hardy-Dessources Marie-Dominique |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-10-20 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 100 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-19 Completed Date: 2006-12-28 Revised Date: 2007-05-01 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 427-32 Citation Subset: IM |
Affiliation:
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Laboratoire Adaptation au Climat Tropical, Exercice et Société Unité Propre de Recherche de l'Enseignment Supérieur-Equipe d'Accueil 3596, Université des Antilles et de la Guyane, Campus de Fouillole, Pointe-à- Pitre Cedex, Guadeloupe. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Erythrocyte Membrane / metabolism* Exercise / physiology Exercise Test Humans Lactic Acid / blood* Monocarboxylic Acid Transporters / metabolism* Oxygen Consumption Sickle Cell Trait / blood* Symporters / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Monocarboxylic Acid Transporters; 0/Symporters; 0/monocarboxylate transport protein 1; 50-21-5/Lactic Acid |
| Comments/Corrections | |
Erratum In:
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J Appl Physiol. 2006 Jul;101(1):372 Note: Fagnété, Sara [corrected to Sara, Fagnété]; Philippe, Connes [corrected to Connes, Philippe]; Olivier, Hue [corrected to Hue, Olivier]; Mona, Montout-Hedreville [corrected to Montout-Hedreville, Mona]; Maryse, Etienne-Julan [corrected to Etienne-Julan, Maryse]; Marie-Dominique, Hardy-Dessources [corrected to Hardy-Dessources, Marie-Dominique] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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