Document Detail


Faster healing of venous ulcers with crystacide: a clinical and microcirculatory 8-week registry study.
MedLine Citation:
PMID:  20657528     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
AIM: This registry evaluated the result of treatment with Crystacide in 73 patients with chronic venous insufficiency (CVI) and ulcerations. The local application of a hydrogen peroxide cream (Crystacide, Sandoz) onto the skin was evaluated with clinical and microcirculatory parameters. After briefing, one group used Crystacide and standard management for ulcers, including compression. A comparable group that did not use Crystacide was also evaluated.
METHODS: Laser Doppler flowmetry (LDF) was used to measure skin perfusion in association with skin TcP02 and TcPCO2. Crystacide was applied around and on the ulcer area for a period between 6 and 9 weeks (with a target time of observation of 8 weeks).
RESULTS: Treatment with Crystacide was more effective. The increased skin flux at inclusion (indicating venus hypertension and microangiopathy) decreased in both groups (improving); TcO2 was increased (P<0.05) and TcCO2 was decreased (P<0.05) in both groups. However, changes in the microcirculatory parameters were significantly larger in the Crystacide group. The average ulcer area was significantly smaller at the average target time of 8 weeks in the Crystacide group in comparison with controls (P<0.05). In the Crystacide group 64.86% of the ulcers were completely healed at 8 weeks versus 38.88% in controls. The difference (+25.98%) in the treatment group is significant (P<0.002).
CONCLUSION: Local treatment with Crystacide improves the healing of venous ulcerations by improving skin perfusion.
Authors:
M R Cesarone; G Belcaro; B M Errichi; A Ricci; P Bavera; E Ippolito; M Dugall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Panminerva medica     Volume:  52     ISSN:  1827-1898     ISO Abbreviation:  Panminerva Med     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421110     Medline TA:  Panminerva Med     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  11-4     Citation Subset:  IM    
Affiliation:
Irvine3 Labs, Department Biomedical Sciences, Chieti-Pescara University, Pescara, Italy.
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