Document Detail

Fast synaptic inhibition in spinal sensory processing and pain control.
MedLine Citation:
PMID:  22298656     Owner:  NLM     Status:  MEDLINE    
The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy conditions, they limit the excitability of spinal terminals of primary sensory nerve fibers and of intrinsic dorsal horn neurons through pre- and postsynaptic mechanisms, and thereby facilitate the spatial and temporal discrimination of sensory stimuli. Removal of fast inhibition not only reduces the fidelity of normal sensory processing but also provokes symptoms very much reminiscent of pathological and chronic pain syndromes. This review summarizes our knowledge of the molecular bases of spinal inhibitory neurotransmission and its organization in dorsal horn sensory circuits. Particular emphasis is placed on the role and mechanisms of spinal inhibitory malfunction in inflammatory and neuropathic chronic pain syndromes.
Hanns Ulrich Zeilhofer; Hendrik Wildner; Gonzalo E Yévenes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Physiological reviews     Volume:  92     ISSN:  1522-1210     ISO Abbreviation:  Physiol. Rev.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-02-02     Completed Date:  2012-03-27     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0231714     Medline TA:  Physiol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  193-235     Citation Subset:  IM    
Institute of Pharmacology and Toxicology, University of Zurich, Switzerland.
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MeSH Terms
Glycine / physiology
Interneurons / physiology
Neurotransmitter Agents / physiology*
Pain / physiopathology*
Posterior Horn Cells / physiology*
Sensory Receptor Cells / physiology
Synaptic Transmission / physiology*
gamma-Aminobutyric Acid / physiology
Grant Support
250128//European Research Council
Reg. No./Substance:
0/Neurotransmitter Agents; 56-12-2/gamma-Aminobutyric Acid; 56-40-6/Glycine

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