Document Detail


Fast and reproducible method for the direct quantitation of adipose tissue in newborn infants.
MedLine Citation:
PMID:  11878317     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of body fat content and distribution in infants is becoming an area of increasing interest, especially as perception of its function appears to be rapidly evolving. Although a number of methods are available to estimate body fat content in adults, many are of limited use in infants, especially in the context of regional distribution and internal depots. In this study we developed and implemented a whole-body magnetic resonance imaging (MRI)-based protocol that allows fast and reproducible measurements of adipose tissue content in newborn infants, with an intra-observer variability of <2.4% and an inter-observed variability of <7%. The percentage total body fat for this cohort of infants ranged from 13.3-22.6% (mean and standard deviation: 16.6 +/- 2.9%), which agrees closely with published data. Subcutaneous fat accounted for just over 89% of the total body fat, whereas internal fat corresponded to almost 11%, most of which was nonabdominal fat. There were no gender differences in total or regional body fat content. These results show that whole-body MRI can be readily applied to the study of adipose tissue content and distribution in newborn infants. Furthermore, its noninvasive nature makes it an ideal method for longitudinal and interventional studies in newborn infants.
Authors:
T A M Harrington; E L Thomas; N Modi; G Frost; G A Coutts; J D Bell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  37     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-03-05     Completed Date:  2002-09-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  95-100     Citation Subset:  IM    
Affiliation:
The Robert Steiner MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / anatomy & histology*
Body Composition
Female
Humans
Infant, Newborn*
Magnetic Resonance Imaging / methods*
Male

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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