| Fast release of lipophilic agents from circulating PEG-PDLLA micelles revealed by in vivo forster resonance energy transfer imaging. | |
| | |
MedLine Citation:
|
PMID: 18257595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Understanding the in vivo behavior of nanoparticles is critical for the translation of nanomedicine from laboratory research to clinical trials. In this work, in vivo Forster resonance energy transfer (FRET) imaging was employed to monitor the release of hydrophobic molecules from circulating poly(ethylene glycol)-poly( D, L-lactic acid) (PEG-PDLLA) micelles. A lipophilic FRET pair (DiIC(18) and DiOC(18)) was physically entrapped into micelle cores by mimicking the loading of hydrophobic drugs. The FRET efficiency was found significantly reduced within 15 min after intravenous injection, implying that DiIC(18) and DiOC(18) quickly escaped from the circulating micelles. FRET spectroscopy studies further demonstrated that alpha- and beta-globulins were major factors for the observed fast release, while gamma-globulins, albumin, and red blood cells played minor roles. These results provide useful information for developing blood-stable micelles to deliver hydrophobic drugs to the target site via prolonged circulation and extravasation from the vascular system. |
| | |
Authors:
|
Hongtao Chen; Sungwon Kim; Wei He; Haifeng Wang; Philip S Low; Kinam Park; Ji-Xin Cheng |
Related Documents
:
|
2095135 - Significance of empty liposomes alone and as drug carriers in dermatotherapy. 16889925 - Assessment of survival of aging erythrocyte in circulation and attendant changes in siz... 2269265 - Scintigraphic evaluation of digital circulation during the developmental and acute phas... 7622365 - A proposed blood circulation model for reference man. 10781995 - B19 parvovirus-induced fetal hydrops:good outcome after intrauterine blood transfusion ... 22181515 - Dynamics and stability of two-potential flows in the porous media. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2008-02-08 |
Journal Detail:
|
Title: Langmuir : the ACS journal of surfaces and colloids Volume: 24 ISSN: 0743-7463 ISO Abbreviation: Langmuir Publication Date: 2008 May |
Date Detail:
|
Created Date: 2008-05-13 Completed Date: 2008-07-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9882736 Medline TA: Langmuir Country: United States |
Other Details:
|
Languages: eng Pagination: 5213-7 Citation Subset: IM |
Affiliation:
|
Department of Chemistry, Weldon School of Biomedical Engineering, and Oncological Sciences Center, Purdue University, West Lafayette, Indiana 47907, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alpha-Globulins
/
chemistry Animals Beta-Globulins / chemistry Biophysics / methods Cattle Drug Carriers / chemistry Erythrocytes / metabolism Fluorescence Resonance Energy Transfer / methods* Mice Mice, Inbred BALB C Micelles* Nanotechnology Polyesters / chemistry* Polyethylene Glycols / chemistry* Polymers / chemistry Serum Albumin / chemistry Spectrometry, Fluorescence |
| Grant Support | |
ID/Acronym/Agency:
|
GM065284/GM/NIGMS NIH HHS; HL078715/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Alpha-Globulins; 0/Beta-Globulins; 0/Drug Carriers; 0/Micelles; 0/Polyesters; 0/Polyethylene Glycols; 0/Polymers; 0/Serum Albumin; 0/polyethylene glycol-polylactide-polyethylene glycol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Production of uniform-sized polymer core-shell microcapsules by coaxial electrospraying.
Next Document: Are inhaled systemic therapies a viable option for the treatment of the elderly patient?