Document Detail


Fast prediction of hydration free energies from molecular interaction fields.
MedLine Citation:
PMID:  11774999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel empirical model is presented that allows the fast computation of hydration free energies with high accuracy. The linear model is based upon the separation of the free energy of hydration into a cavity and an interaction term. The cavity contribution is modeled as a linear combination of molecular volume and surface terms. The interaction part is derived from the statistical three-dimensional (3D) free energy density and is modeled approximately as a molecular interaction field using the program GRID. A compression scheme is employed to represent this 3D information on the molecular surface by means of a linear combination of surface functions. A set of 81 small organic molecules with known experimental hydration free energies is used to determine the coefficients of the linear model by least squares regression. The fit is statistically significant yielding a correlation coefficient of 0.99, a root mean square error of 0.27 kcal/mol for the 81 molecules belonging to the training set, and 0.63 kcal/mol for an independent test set of 10 molecules.
Authors:
R Jäger; S M Kast
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of molecular graphics & modelling     Volume:  20     ISSN:  1093-3263     ISO Abbreviation:  J. Mol. Graph. Model.     Publication Date:  2001  
Date Detail:
Created Date:  2001-12-31     Completed Date:  2002-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9716237     Medline TA:  J Mol Graph Model     Country:  United States    
Other Details:
Languages:  eng     Pagination:  123-31     Citation Subset:  IM    
Affiliation:
Institut für Physikalische Chemie, Technische Universität Darmstadt, Germany. robertm.jaeger@aventis.com
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MeSH Terms
Descriptor/Qualifier:
Computer Simulation*
Drug Design*
Models, Chemical
Models, Molecular
Quantitative Structure-Activity Relationship
Thermodynamics
Water
Chemical
Reg. No./Substance:
7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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