Document Detail


Fast-melting tablets based on highly plastic granules.
MedLine Citation:
PMID:  16260059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Highly plastic granules that can be compressed into tablets at low pressure were developed to make fast-melting tablets (FMTs) by compression method. The highly plastic granules are composed of three components: a plastic material, a material enhancing water penetration, and a wet binder. One of the unique properties of the highly plastic granules is that they maintain a porous structure even after compression into tablets. The porous and plastic nature of the granules allows fast absorption of water into the compressed tablet for fast melting/dissolution of the tablet. The prepared tablets possess tablet strength and friability that are suitable for multi-tablet packages. The three-component highly plastic granules provide an effective way of making FMTs by compression.
Authors:
Yourong Fu; Seong Hoon Jeong; Kinam Park
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-02
Journal Detail:
Title:  Journal of controlled release : official journal of the Controlled Release Society     Volume:  109     ISSN:  0168-3659     ISO Abbreviation:  J Control Release     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-07     Completed Date:  2006-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607908     Medline TA:  J Control Release     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  203-10     Citation Subset:  IM    
Affiliation:
Akina Inc., West Lafayette, IN 47906, USA.
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MeSH Terms
Descriptor/Qualifier:
Chemistry, Pharmaceutical*
Excipients
Hardness
Microscopy, Electron, Scanning
Particle Size
Permeability
Plastics / chemistry*
Powders
Solubility
Tablets*
Water / chemistry
Chemical
Reg. No./Substance:
0/Excipients; 0/Plastics; 0/Powders; 0/Tablets; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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