Document Detail


Fast amplification of dynamic synaptic inputs in spinal motoneurons in vivo.
MedLine Citation:
PMID:  16823025     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of voltage-dependent inward currents (likely Na(+)) of the adult cat lumbar motoneurons to amplify rapidly changing (i.e., dynamic) synaptic inputs was investigated using in vivo intracellular recording techniques. Fast amplification was assessed by measuring the magnitude of the high-frequency (180 Hz) component of the Ia synaptic input due to tendon vibration as a function of somatic voltage and was compared with the previously observed amplification of steady inputs (steady state response of PICs to slow inputs). Data from 17 experiments show that amplification of the dynamic input indeed occurred and was directly linked to neuromodulatory drive (standard state: decerebrate with intact descending neuromodulatory systems vs. minimal state: pentobarbital with said systems significantly inhibited). Fast amplification factors averaged 2.0 +/- 0.7 (mean +/- SD) in the standard neuromodulatory state. That is, the effective synaptic current was nearly twice as large at its peak as it was at hyperpolarized levels, ranging as high as 2.6. Although fast amplification was often smaller than the amplification of steady inputs, the difference was not statistically significant. However, the voltage at which fast amplification began was approximately 10 mV more depolarized (P < 0.01). It is concluded that both dynamic and steady inputs can be amplified, but there may be differences in mechanism.
Authors:
Sarah M Jones; Robert H Lee
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-07-05
Journal Detail:
Title:  Journal of neurophysiology     Volume:  96     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-16     Completed Date:  2006-12-06     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2200-6     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, Georgia Institute of Technology, Whitaker Bldg., 3103, 313 Ferst Dr., Atlanta, GA 30332, USA.
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MeSH Terms
Descriptor/Qualifier:
Achilles Tendon / innervation
Anesthesia
Animals
Cats
Decerebrate State / physiopathology
Kinetics
Motor Neurons / physiology*
Pentobarbital
Physical Stimulation
Spinal Cord / cytology*,  physiology*
Synapses / physiology*
Vibration
Grant Support
ID/Acronym/Agency:
NS-045199/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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