Document Detail

Fast, acid-free, and selective lactamization of lactones in ionic liquids.
MedLine Citation:
PMID:  18826282     Owner:  NLM     Status:  MEDLINE    
A fast and acid-free one-pot 0.2-30 mmol microwave methodology for direct ionic liquid-mediated preparation of lactams from lactones and primary amines has been developed. The protocol was investigated with a wide range of primary amines and a handful of lactones, including substrates with acid-sensitive substituents. Both gamma-lactams and delta-lactams were, despite the complete absence of a Brønsted acid, obtained in useful to excellent yields after only 35 min of microwave processing.
Kristina M Orrling; Xiongyu Wu; Francesco Russo; Mats Larhed
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-01
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  73     ISSN:  1520-6904     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-31     Completed Date:  2009-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8627-30     Citation Subset:  IM    
Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala Biomedical Center, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden.
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MeSH Terms
Ionic Liquids*
Lactams / chemistry*
Lactones / chemistry*
Reg. No./Substance:
0/Ionic Liquids; 0/Lactams; 0/Lactones

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