Document Detail


Fast Detection of Renal Ischemia in Transplanted Kidneys With Delayed Graft Function-An Experimental Study.
MedLine Citation:
PMID:  23325002     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The newly transplanted kidney is difficult to monitor with regard to postoperative vascular thrombosis, especially when there is delayed graft function. We evaluated microdialysis as a tool for early ischemia detection in porcine kidneys with delayed graft function early after transplantation. METHODS: Sixteen pigs were transplanted with 26-hr cold ischemia kidneys. A microdialysis catheter was placed in the lateral renal cortex. Five hours after graft reperfusion, the pigs were randomized to renal arterial clamping or open artery, n=8 in each group, and further observed for 2 hr. RESULTS: The diuresis and glomerular filtration rate were low and decreasing throughout the study, with no significant differences between groups. Until arterial clamping, there were no significant differences in the development of local renal metabolites between the two groups. Renal artery clamping immediately caused significantly different development of all metabolites (P<0.02 for all) compared to the open artery group. After clamping, levels of glutamate and glycerol were significantly increased within 30 min (P=0.0049 and P=0.0061, respectively). CONCLUSIONS: Microdialysis provided an early warning of arterial occlusion in transplanted grafts with delayed graft function. It may become a valuable tool for postoperative monitoring and detection of thrombosis after renal transplantation.
Authors:
Anna K Keller; Troels M Jørgensen; Dorthe M Vittrup; Ulrik K Kjerkegaard; Bente Jespersen; Søren R P Krag; Bo M Bibby; Lars B Stolle
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Transplantation     Volume:  95     ISSN:  1534-6080     ISO Abbreviation:  Transplantation     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  275-279     Citation Subset:  -    
Affiliation:
1Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark. 2Department of Urology, Aarhus University Hospital, Aarhus, Denmark. 3Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark. 4 Department of Pathology, Aarhus University Hospital, Aarhus, Denmark. 5Department of Biostatistics, Aarhus University, Aarhus, Denmark. 6Department of Plastic Surgery, Aarhus University Hospital, Aarhus, Denmark. 7Address correspondence to: Anna Krarup Keller, M.D., Ph.D., Institute of Clinical Medicine, Aarhus University Hospital, Skejby, Brendstrupgaardsvej 100, DK-8200 Aarhus N, Denmark.
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