Document Detail


Fasciola hepatica: collagen deposition and other histopathology in the rat host's bile duct caused by the parasite and by proline infusion.
MedLine Citation:
PMID:  6499998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bile ducts were examined histochemically to compare the effects of proline infusion with Fasciola hepatica implantation in rats. After 3 weeks of infusion or implantation, both proline and F. hepatica produced increases in the luminal perimeter and collagen content of the bile duct. However, the effect of the parasite was significantly greater than that of proline, and the parasite produced significant increases in the bile duct wall. These results corroborate earlier biochemical and histological studies indicating the important role of proline in the enlargement of the bile duct in fascioliasis.
Authors:
S Modavi; H Isseroff
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental parasitology     Volume:  58     ISSN:  0014-4894     ISO Abbreviation:  Exp. Parasitol.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1984-12-31     Completed Date:  1984-12-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370713     Medline TA:  Exp Parasitol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  239-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile Ducts / analysis*,  pathology
Collagen / analysis*
Fasciola hepatica / metabolism*
Fascioliasis / metabolism*,  parasitology,  pathology
Histocytochemistry
Inflammation
Male
Proline / biosynthesis,  pharmacology*
Rats
Grant Support
ID/Acronym/Agency:
A109911//PHS HHS
Chemical
Reg. No./Substance:
147-85-3/Proline; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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