| Fascin: a key regulator of cytoskeletal dynamics. | |
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MedLine Citation:
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PMID: 20601080 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fascin is a 55 kDa actin-bundling protein and is an important regulatory element in the maintenance and stability of parallel bundles of filamentous actin in a variety of cellular contexts. Regulation of fascin function is under the control of a number of different signalling pathways that act in concert to spatially regulate the actin-binding properties of this protein. The ability of fascin to bind and bundle actin plays a central role in the regulation of cell adhesion, migration and invasion. Fascin has received considerable attention recently as an emerging key prognostic marker of metastatic disease. Studies are now underway to better understand the precise regulation of this protein in the context of tumour progression and to investigate fascin as a potential therapeutic target for a number of forms of cancer. |
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Authors:
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Asier Jayo; Maddy Parsons |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-06-30 |
Journal Detail:
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Title: The international journal of biochemistry & cell biology Volume: 42 ISSN: 1878-5875 ISO Abbreviation: Int. J. Biochem. Cell Biol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2011-03-09 Revised Date: 2011-04-04 |
Medline Journal Info:
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Nlm Unique ID: 9508482 Medline TA: Int J Biochem Cell Biol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1614-7 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Randall Division of Cell and Molecular Biophysics, King's College London, London, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carrier Proteins / genetics, metabolism* Cell Adhesion Cell Movement Cytoskeleton / metabolism* Disease Progression Gene Expression Regulation, Neoplastic Humans Microfilament Proteins / genetics, metabolism* Neoplasm Metastasis Neoplasms / diagnosis*, pathology, physiopathology Prognosis Signal Transduction Tumor Markers, Biological / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Microfilament Proteins; 0/Tumor Markers, Biological; 146808-54-0/fascin |
| Comments/Corrections | |
Erratum In:
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Int J Biochem Cell Biol. 2011 Apr;43(4):691 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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