Document Detail

Fasciculations and cramps: how benign? Report of four cases progressing to ALS.
MedLine Citation:
PMID:  20967550     Owner:  NLM     Status:  In-Data-Review    
Clinical diagnosis of amyotrophic lateral sclerosis (ALS) in patients presenting with cramps and fasciculations may not be evident at the first consultation. Sequential reviews, clinical and neurophysiological, form an important part of clinical practice in such cases. Recent attempts to delineate a more benign group with cramps and fasciculations have lacked information on the long term profile, both clinical and neurophysiological. Four patients who were initially diagnosed as suffering from benign cramps and fasciculations, but who subsequently progressed to ALS, are described. We propose that a diagnosis of benign cramps and fasciculations should not be considered secure without a minimum follow up of 4-5 years.
Varun Singh; John Gibson; Brendan McLean; Mike Boggild; Nicholas Silver; Richard White
Publication Detail:
Type:  Journal Article     Date:  2010-10-22
Journal Detail:
Title:  Journal of neurology     Volume:  258     ISSN:  1432-1459     ISO Abbreviation:  J. Neurol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  573-8     Citation Subset:  IM    
Department of Neurology, The Walton Centre for Neurology and Neurosurgery, Lower Lane, Liverpool, L9 7AJ, UK,
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