Document Detail

Fas signaling is involved in the control of hair follicle response to chemotherapy.
MedLine Citation:
PMID:  15342414     Owner:  NLM     Status:  MEDLINE    
Chemotherapeutic agents induce p53-dependent apoptosis in the hair follicle (HF) resulting in hair loss, a common side effect of cancer therapy. Here, we show that Fas as a p53 target plays important role in the HF response to cyclophosphamide. Specifically, we demonstrate that Fas is up-regulated in HF keratinocytes after cyclophosphamide treatment, Fas ligand-neutralizing antibody partially inhibits HF response to cyclophosphamide in wild-type mice, and Fas knockout mice show significant retardation of cyclophosphamide-induced HF involution associated with reduced Fas-associated death domain and caspase-8 expression. These data raise a possibility to explore blockade of Fas signaling as a part of complex local therapy for inhibiting keratinocyte apoptosis and hair loss induced by chemotherapy.
Andrei A Sharov; Frank Siebenhaar; Tatyana Y Sharova; Natalia V Botchkareva; Barbara A Gilchrest; Vladimir A Botchkarev
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  64     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-02     Completed Date:  2004-10-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6266-70     Citation Subset:  IM    
Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
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MeSH Terms
Adaptor Proteins, Signal Transducing*
Antibodies / immunology,  pharmacology
Antigens, CD95 / metabolism,  physiology*
Antineoplastic Agents, Alkylating / pharmacology*
Apoptosis / drug effects
Carrier Proteins / biosynthesis
Caspase 8
Caspases / biosynthesis
Cyclophosphamide / pharmacology*
Fas Ligand Protein
Fas-Associated Death Domain Protein
Hair Follicle / drug effects*,  physiology*
In Situ Nick-End Labeling
Keratinocytes / cytology,  drug effects
Membrane Glycoproteins / antagonists & inhibitors,  immunology,  metabolism
Mice, Inbred C57BL
Mice, Knockout
Signal Transduction
Grant Support
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Antibodies; 0/Antigens, CD95; 0/Antineoplastic Agents, Alkylating; 0/Carrier Proteins; 0/Fadd protein, mouse; 0/Fas Ligand Protein; 0/Fas-Associated Death Domain Protein; 0/Fasl protein, mouse; 0/Membrane Glycoproteins; 50-18-0/Cyclophosphamide; EC 3.4.22.-/Casp8 protein, mouse; EC 3.4.22.-/Caspase 8; EC 3.4.22.-/Caspases

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