| Fas activation in adipocytes impairs insulin-stimulated glucose uptake by reducing Akt. | |
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MedLine Citation:
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PMID: 20828573 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fas (CD95) belongs to the superfamily of the tumor necrosis factor (TNF) receptors. Besides its key role in apoptosis, Fas contributes to non-apoptotic pathways such as cell proliferation and inflammation. In 3T3-L1 adipocytes, activation of Fas by Fas ligand decreased insulin-stimulated glucose uptake, without affecting cell viability. This decrease in glucose uptake was accompanied by reduced protein expression and diminished phosphorylation of Akt. Similarly, insulin-stimulated glucose incorporation and protein levels of Akt were increased in isolated adipocytes from Fas deficient mice when compared to wild-type mice. In conclusion, Fas activation in adipocytes decreases Akt expression and thereby impairs insulin sensitivity. |
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Authors:
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Stephan Wueest; Reto A Rapold; Eugen J Schoenle; Daniel Konrad |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-07 |
Journal Detail:
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Title: FEBS letters Volume: 584 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 4187-92 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Division of Pediatric Endocrinology and Diabetology, University Children's Hospital, Zurich, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3T3-L1 Cells Adipocytes, White / drug effects*, metabolism* Animals Antigens, CD95 / deficiency, genetics, metabolism* Biological Transport, Active / drug effects Fas Ligand Protein / metabolism, pharmacology Glucose / metabolism* Insulin / pharmacology* Mice Mice, Inbred C57BL Mice, Knockout Proto-Oncogene Proteins c-akt / metabolism* Signal Transduction / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD95; 0/Fas Ligand Protein; 0/Fas protein, mouse; 0/Fasl protein, mouse; 11061-68-0/Insulin; 50-99-7/Glucose; EC 2.7.11.1/Proto-Oncogene Proteins c-akt |
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