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Fas-FasL System in Molar Pregnancy.
MedLine Citation:
PMID:  21087335     Owner:  NLM     Status:  In-Data-Review    
Citation Soni S, Rath G, Prasad CP, Salhan S, Jain AK, Saxena S. Fas-FasL system in molar pregnancy. Am J Reprod Immunol 2011; 65: 512-520 Problem  Hydatidiform mole (molar pregnancy) is the commonest form of Gestational Trophoblastic Disease, with the risk of undergoing malignant transformation. The molecular pathway leading to pathogenesis and progression of molar pregnancy is barely understood. The study focuses on Fas/FasL system which represents one of the main apoptotic pathways controlling placental morphogenesis. Method of study  Placental tissues from 52 patients with complete hydatidiform moles (CHMs) and 55 age-matched controls were examined for Fas and FasL expression using immunohistochemistry, immunofluorescence and Western blotting. The protein expression was also correlated with trophoblast apoptosis (assessed by M30 Cyto DEATH), clinico-pathological parameters and disease progression. Results  Immunohistochemistry and immunofluorescence revealed both cytoplasmic and membranous expression of Fas in villous syncytiotrophoblast as well as cytotrophoblast but FasL was confined merely to the cytoplasm of syncytiotrophoblast. Both Fas (cytoplasm and membrane) and FasL were significantly upregulated in syncytiotrophoblast of CHMs (P = 0.004, P < 0.0001 and P < 0.0002 respectively) and showed a positive association between them (P = 0.019). However, none of the proteins reveal any correlation with M30 index. The results were revalidated using Western blotting. Conclusion  This study demonstrated differential expression of Fas and FasL in CHMs and its implications in the pathogenesis of molar pregnancy has been discussed.
Simmi Soni; Gayatri Rath; Chandra Prakash Prasad; Sudha Salhan; Arun Kumar Jain; Sunita Saxena
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Publication Detail:
Type:  Journal Article     Date:  2010-11-19
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  65     ISSN:  1600-0897     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  512-20     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons A/S.
Department of Anatomy, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India Institute of Pathology - ICMR, New Delhi, India.
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