Document Detail


Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells.
MedLine Citation:
PMID:  20298756     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increased expression of farnesyl diphosphate synthase (FPPS) by stable transfection appeared to attenuate paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells. The present results suggest that the apoptotic functions of p53 and c-Jun N-terminal kinase (JNK) are affected by FPPS. Farnesyl diphosphate, a catalytic product of FPPS, also attenuated mentioned paclitaxel-induced apoptotic cell death. As expected, the FPPS inhibitor, pamidronate, enhanced paclitaxel-induced apoptotic cell death. The present results suggest that FPPS plays an important role in apoptotic cell death of cancer cells by blocking the JNK signaling cascade and activating mevalonate metabolism in paclitaxel-treated glioblastoma cells.
Authors:
Im Sun Woo; So Young Eun; Hyo Jung Kim; Eun Sil Kang; Hye Jung Kim; Jae Heun Lee; Ki Churl Chang; Jin-Hoi Kim; Soon-Chan Hong; Han Geuk Seo
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Publication Detail:
Type:  Journal Article     Date:  2010-03-15
Journal Detail:
Title:  Neuroscience letters     Volume:  474     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  115-20     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Pharmacology, Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, 92 Chilam-dong, Jinju 660-751, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / pharmacology*
Apoptosis / drug effects*
Cell Line, Tumor
Cell Survival / drug effects
Diphosphonates / pharmacology
Drug Synergism
Flow Cytometry / methods
Geranyltranstransferase / genetics,  metabolism*
Glioblastoma / pathology,  physiopathology
Humans
JNK Mitogen-Activated Protein Kinases / metabolism
Mevalonic Acid / pharmacology
Paclitaxel / pharmacology*
Polyisoprenyl Phosphates / metabolism
Sesquiterpenes / metabolism
Signal Transduction / drug effects
Time Factors
Tumor Suppressor Protein p53 / metabolism
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Diphosphonates; 0/Polyisoprenyl Phosphates; 0/Sesquiterpenes; 0/Tumor Suppressor Protein p53; 13058-04-3/farnesyl pyrophosphate; 150-97-0/Mevalonic Acid; 33069-62-4/Paclitaxel; 40391-99-9/pamidronate; EC 2.5.1.10/Geranyltranstransferase; EC 2.7.11.24/JNK Mitogen-Activated Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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