Document Detail


Farnesol and cyclic AMP signaling effects on the hypha-to-yeast transition in Candida albicans.
MedLine Citation:
PMID:  22886999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Candida albicans, a fungal pathogen of humans, regulates its morphology in response to many environmental cues and this morphological plasticity contributes to virulence. Farnesol, an autoregulatory molecule produced by C. albicans, inhibits the induction of hyphal growth by inhibiting adenylate cyclase (Cyr1). The role of farnesol and Cyr1 in controlling the maintenance of hyphal growth has been less clear. Here, we demonstrate that preformed hyphae transition to growth as yeast in response to farnesol and that strains with increased cyclic AMP (cAMP) signaling exhibit more resistance to farnesol. Exogenous farnesol did not induce the hypha-to-yeast transition in mutants lacking the Tup1 or Nrg1 transcriptional repressors in embedded conditions. Although body temperature is not required for embedded hyphal growth, we found that the effect of farnesol on the hypha-to-yeast transition varies inversely with temperature. Our model of Cyr1 activity being required for filamentation is also supported by our liquid assay data, which show increased yeast formation when preformed filaments are treated with farnesol. Together, these data suggest that farnesol can modulate morphology in preformed hyphal cells and that the repression of hyphal growth maintenance likely occurs through the inhibition of cAMP signaling.
Authors:
Allia K Lindsay; Aurélie Deveau; Amy E Piispanen; Deborah A Hogan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-10
Journal Detail:
Title:  Eukaryotic cell     Volume:  11     ISSN:  1535-9786     ISO Abbreviation:  Eukaryotic Cell     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-02-21     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101130731     Medline TA:  Eukaryot Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1219-25     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenylate Cyclase / genetics,  metabolism
Candida albicans / genetics,  growth & development*,  metabolism
Cyclic AMP / metabolism*
Farnesol / pharmacology*
Fungal Proteins / genetics,  metabolism
Hyphae / drug effects,  growth & development*,  metabolism
Repressor Proteins / genetics,  metabolism
Signal Transduction
Transcription, Genetic / genetics
Grant Support
ID/Acronym/Agency:
5T32GM008704/GM/NIGMS NIH HHS; K22 DE016542/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Fungal Proteins; 0/Repressor Proteins; 4602-84-0/Farnesol; 60-92-4/Cyclic AMP; EC 4.6.1.1/Adenylate Cyclase
Comments/Corrections

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